Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1.5

DOI: 10.1021/jm0210461

Source and publish data:

Journal of Medicinal Chemistry p. 486 - 498 (2003)

Update date:2022-07-30

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Authors:

Peukert, Stefan

Brendel, Joachim

Pirard, Bernard

Brüggemann, Andrea

Below, Peter

Kleemann, Heinz-Werner

Hemmerle, Horst

Schmidt, Wolfgang

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Article abstract of DOI:10.1021/jm0210461

The voltage-gated potassium channel Kv1.5 is regarded as a promising target for the development of new atrial selective drugs with fewer side effects. In the present study the discovery of ortho, ortho-disubstituted bisaryl compounds as blockers of the Kv

Full text of DOI:10.1021/jm0210461

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