
Chemistry of Heterocyclic Compounds p. 352 - 355 (1980)
Update date:2022-08-03
Topics:
Bubel', O.N.
Tishchenko, I.G.
Grinkevich, O.A.
Abramov, A.F.
The reaction of 2-acetyloxiranes with alkyl thiocyanates in the presence of Lewis acids (BF3, AlCl3) has given 2-alkylthio-5-acetyl-2-oxazolines (yields 40-60percent).It has been shown that the reaction of trans-2-acetyl-3-methyloxirane and of trans-2-acetyl-3-methyloxirane and of trans-2-acetyl-2,3-dimethyloxirane with alkyl thiocyanates takes place stereospecifically and leads to cis-2-alkylthio-5-acetyl-2-oxazolines.
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