NSAIDS, AGING, AND MUSCLE INJURY
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necessary. For example, Mishra and colleagues (38) showed
that NSAIDs attenuated force decrements in isolated rabbit
muscle early after ECC actions but exacerbated the force
deficit 1 month after injury. They cautioned against the lib-
eral use of NSAIDs, which is common among elderly per-
sons. On the other hand, approximately 1 month following
NSAID therapy in the present study, muscle strength and
MR images indicated full recovery from the ECC bout (un-
published results). Nonetheless, the side effects of NSAIDs
(e.g., gastrointestinal and hepatic stress) mandate proper
medical supervision during prolonged use.
In summary, naproxen sodium administered for 10 days
immediately after novel ECC exercise attenuated muscle in-
jury and soreness and improved strength recovery in older
individuals. These results suggest that NSAIDs might bene-
fit older individuals embarking on a novel program of phys-
ical activity that might induce muscle injury and soreness
and/or compromise function during everyday activities.
Acknowledgments
Naproxen sodium was provided by Procter and Gamble, Inc. (Cincin-
nati, OH), for which we thank Linda Altringer. This research was supported
in part by a University of Georgia Graduate School Fellowship (SWS). We
thank St. Mary’s Hospital of Athens, GA, in particular Debbie Eliopulos,
for magnetic resonance imaging.
Address correspondence to Gary A. Dudley, PhD, Department of Exer-
cise Science, The University of Georgia, 115M Ramsey Center, 300 River
Road, Athens, GA 30602-3654. E-mail: gdudley@coe.uga.edu
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Received June 19, 2000
Accepted July 11, 2000
Decision Editor: John E. Morley, MB, BCh
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