Highly water-soluble matrix metalloproteinases inhibitors and their effects in a rat adjuvant-induced arthritis model.

DOI: 10.1016/S0968-0896(02)00109-8

Source and publish data:

Bioorganic and medicinal chemistry p. 2569 - 2581 (2002)

Update date:2022-08-02

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Authors:

Fujisawa, Tetsunori

Igeta, Katsuhiro

Odake, Shinjiro

Morita, Yasuo

Yasuda, Junko

Morikawa, Tadanori

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Article abstract of DOI:10.1016/S0968-0896(02)00109-8

A new series of succinate-based dual inhibitors against matrix metalloproteinases (MMPs) and tumor necrosis factor alpha converting enzyme (TACE) possessing highly-water solubility was designed, synthesized, and evaluated for enzyme inhibition. Incorporat

Full text of DOI:10.1016/S0968-0896(02)00109-8

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