Bioorganic and medicinal chemistry letters p. 2125 - 2128 (2002)
Update date:2022-08-04
Topics:
Ting, Pauline C
Lee, Joe F
Shih, Neng Yang
Piwinski, John J
Anthes, John C
Chapman, Richard W
Rizzo, Charles A
Hey, John A
Ng, Kwokei
Nomeir, Amin A
A novel series of dual NK(1)/NK(2) receptor antagonists, based on the 2-oxo-(1,4'-bipiperidine) template, has been prepared. Compound 10R is a potent dual NK(1)/NK(2) antagonist and demonstrates excellent in vivo activity and good oral plasma levels in the dog.
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Doi:10.1016/S0040-4039(02)01632-5
(2002)Doi:10.1021/om0207212
(2003)Doi:10.1139/v04-137
(2004)Doi:10.1021/ja411391c
(2014)Doi:10.1002/1099-0682(200210)2002:10<2614::AID-EJIC2614>3.0.CO;2-2
(2002)Doi:10.1016/S0040-4039(01)96127-1
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