Glycosyl thioimidates in a highly convergent one-pot strategy for oligosaccharide synthesis

Article abstract of DOI:10.1016/j.tetasy.2004.11.029

Application of two classes of thioimidoyl derivatives, S-benzoxazolyl (SBox) and S-thiazolyl (STaz) glycosides to selective activation over thioglycosides is described. These results allowed us to synthesize a tetrasaccharide derivative using a leaving group differentiated one-pot strategy in 73% yield over three sequential glycosylation steps.