Syntheses of (14 beta,17 alpha)-14-hydroxy- and (14 beta,17 alpha)-2, 14-dihydroxyestradiols and their activities.

Article abstract of DOI:10.1271/bbb.60.411

Structure 1 is proposed for the Inagami-Tamura endogenous digitalis-like factor (EDLF), and (14 beta,17 alpha)-14-hydroxy- and (14 beta,17 alpha)-2,14-dihydroxyestradiols (2 and 3) were synthesized as models for studies on 1. The latter compound was remarkably potent in inducing a contractile response in isolated rat aorta and guinea pig left atrium.

Full text of DOI:10.1271/bbb.60.411

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Syntheses of (14β,17α)-14-Hydroxy- and
(14β,17α)-2,14-Dihydroxyestradiols and Their
Activities
Masayuki Sakakibaraa & Aki Ogawa Uchidaa
a Pharmaceutical Research Laboratories, Kirin Brewery Co., Ltd, 3 Miyahara-cho,
Takasaki, Gunma 370–12, Japan
Published online: 12 Jun 2014.
To cite this article: Masayuki Sakakibara & Aki Ogawa Uchida (1996) Syntheses of (14β,17α)-14-Hydroxy- and
(14β,17α)-2,14-Dihydroxyestradiols and Their Activities, Bioscience, Biotechnology, and Biochemistry, 60:3, 411-414, DOI:
10.1271/bbb.60.411
To link to this article: http://dx.doi.org/10.1271/bbb.60.411
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