Journal of Medicinal Chemistry p. 602 - 605 (1973)
Update date:2022-08-05
Topics:
Vida
Hooker
Reinhard
Several phenobarbital and mephobarbital derivatives were found to possess potent anticonvulsant activity and yet were either devoid of the marked hypnotic effects associated with the parent compounds or displayed very weak hypnotic activity. Particularly active compounds were the Mannich type derivatives, the bis(hexamethylenetetramine salt) of 1,3 bis(bromomethyl)phenobarbital and 1 methyl 3 methoxymethylphenobarbital.
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