Photoaddition of Alcohols and Ethers to Flavins in the Presence of EDTA

Article abstract of DOI:10.1016/0040-4039(94)88073-5

Alcohols and ethers that do not normally photoadd to flavins do so in the presence of EDTA to produce covalent attachment of an alkyl group at C(4a).Thus, irradiation of an aerated solution containing both EDTA and t-butanol resulted in rapid formation of an air-stable, reduced flavin, FIH-C(4a)CH2C(CH3)2OH.Similar results were also obtained with ethanol, 1-propanol, 2-propanol, pinacol, poly(ethylene glycol), and dioxane, but not with methanol or acetone.