Reaction of N-(4-oxo-2-methyl-2-pentyl) -α-phenylnitrone with hydroxylamine

Article abstract of DOI:10.1007/BF01199647

1. The reaction of mesityl oxide with anti-benzaldoxime gives the N-alkylation product, namely N-(4-oxo-2-methyl-2-pentyl)-α-phenylnitrone; the reaction is reversible. 2. The treatment of N-(4-oxo-2-methyl-2-pentyl)-α-phenyl-nitrone with hydroxylamine gives N-(4-hydroxyimino-2-methyl-2-pentyl)hydroxylamine and 5-hydroxy-3,3,5-trimethylisoxazolidine. The latter is the intermolecular cyclization product of the intermediate β-hydroxylamine ketone.