2-(trifluoromethyl)quinolines from anilines: A novel mode of isomerization and cyclization

Article abstract of DOI:10.1016/0040-4020(96)00168-8

Deprotonation of N-ethylidene-tert-butylamine with lithium diisopropylamide and subsequent condensation with ethyl trifluoroacetate gives 4-tert-butylamino-1,1,1-trifluorobut-3-en-2-one. An exchange of the amino substituent occurs when the latter compound