Chiral and Achiral Formamidines in Synthesis. The First Asymmetric Route to (-)-Yohimbone and an Efficient Total Synthesis of (+/-)-Yohimbone

Article abstract of DOI:10.1021/ja00222a041

An asymmetric synthesis of (-)-yohimbone from chiral formamidines is presented.The synthetic pathway intercepts a previously reported route to yohimbenone (6) reported by Winterfeldt.An investigation of the <3,3>-rearrangement involving iminium salts 8 an