Journal of Asian Natural Products Research p. 841 - 846,6 (2014)
Update date:2022-07-29
Topics:
Zhang, Zhi-Hui
Deng, An-Jun
Yu, Jin-Qian
Li, Zhi-Hong
Qin, Hai-Lin
Wu, Lian-Qiu
Zhang, Hai-Jing
Wang, Wen-Jie
Quaternary coptisine (1), a natural bioactive quaternary protoberberine alkaloid (QPA), was treated with potassium ferricyanide in aqueous solution of 5 N sodium hydroxide leading to the acquisition of 8-oxocoptisine (2) with much higher yield than reported in the literature. This is the first report of the oxidation of a natural QPA by applying potassium ferricyanide as an oxidant. 8-Oxocoptisine showed significant anti-ulcerative colitis efficacy in vitro with EC50 value being 8.12 × 10-8 M.
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