Synthetic Communications p. 536 - 545 (2016)
Update date:2022-09-26
Topics:
Gürdere, Meliha Burcu
Eme?, Ali Cemal
Aslan, Osman Nuri
Budak, Yakup
Ceylan, Mustafa
The triethylamin-mediated addition of 2-aminoethanethiol hydrochloride to chalcone analogs was investigated. This addition, bearing a 2-thienyl group at the 3-position, gave the only addition adduct at room temperature in 3 h, whereas the chalcones bearing the 2-furyl group at the 1-position gave an addition-cyclization product (1, 4-thiazepine) in the same conditions. The effect of the groups to the reaction was investigated by changing the 1- and 3-position groups. The chalcones bearing the 2-thienyl group at the 1-position and the others afforded the mixture of products in different ratio at rt for 0.5-24 h. Moreover, the addition-cyclization products (1,4-thiazepine) were obtained under reflux conditions in 36 h. The structures of the synthesized compounds were elucidated by 1H NMR, 13C NMR, infrared, and elemental analysis.
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Doi:10.1135/cccc19740333
(1974)Doi:10.1002/ardp.19883210506
(1988)Doi:10.1039/b613641a
(2007)Doi:10.1246/bcsj.68.950
(1995)Doi:10.1021/jm00238a009
(1975)Doi:10.1039/c7dt03142d
(2017)