Chemical and Pharmaceutical Bulletin p. 1999 - 2002 (2000)
Update date:2022-08-04
Topics: Regioselectivity Lewis acid Yield Ketones Solvent Deprotonation Nucleophilic substitution Anhydrous conditions Leaving group Workup Reaction Mechanism Halogenation Quenching Stoichiometry Electrophilic activation Carbonyl Group (C=O)
Nishiyama
Ono
Kurokawa
Kimura
The direct α-bromination of various ketones using trifluoromethanesulfonic anhydride and Grignard reagent or magnesium bromide in ether gave the corresponding α-bromo ketones in moderate to good yields under mild reaction conditions.
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(2003)
