Trifluoromethanesulfonic anhydride-promoted α-bromination of ketones with Grignard reagent or magnesium bromide

DOI: 10.1248/cpb.48.1999

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1999 - 2002 (2000)

Update date:2022-08-04

Topics: Regioselectivity Lewis acid Yield Ketones Solvent Deprotonation Nucleophilic substitution Anhydrous conditions Leaving group Workup Reaction Mechanism Halogenation Quenching Stoichiometry Electrophilic activation Carbonyl Group (C=O)

Authors:

Nishiyama

Ono Ono

Kurokawa

Kimura Kimura

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Article abstract of DOI:10.1248/cpb.48.1999

The direct α-bromination of various ketones using trifluoromethanesulfonic anhydride and Grignard reagent or magnesium bromide in ether gave the corresponding α-bromo ketones in moderate to good yields under mild reaction conditions.

Full text of DOI:10.1248/cpb.48.1999

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