Quaternization and dequaternization of pyrazoles in solvent- free conditions: Conventional heating versus microwave irradiation

Article abstract of DOI:10.1002/jhet.5570360410

We report a study on the quaternization and dequaternization of pyrazoles by conventional heating and microwave irradiation in solvent-free conditions. Microwave irradiation produces an acceleration in the quaternization rate and a rapid equilibration between quaternized and non quaternized products. Dequaternization is also more rapid and a change on the selectivity is observed using symmetric pyrazolium salts.