Bioorganic and Medicinal Chemistry Letters p. 3836 - 3839 (2015)
Update date:2022-08-03
Topics:
Baugh, Simon D.P.
Pabba, Praveen K.
Barbosa, Joseph
Coulter, Eric
Desai, Urvi
Gay, Jason P.
Gopinathan, Suma
Han, Qiang
Hari, Rajee
Kimball, S. David
Nguyen, Huy V.
Ni, Chi-You
Powell, David R.
Smith, Arian
Terranova, Kristen M.
Wilson, Alan
Yu, Xuan-Chuan
Lombardo, Victoria K.
The synthesis, SAR, and in vivo activity of inhibitors of delta-5 desaturase are described. Ring-constraint of the initial series provided access to a variety of in vitro active chemotypes, from which the indazole was selected. Examples from the indazole
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