Journal of Organic Chemistry p. 6076 - 6082 (1993)
Update date:2022-08-03
Topics:
Kalaus, Gyoergy
Greiner, Istvan
Kajtar-Peredy, Maria
Brlik, Janos
Szabo, Lajos
Szantay, Csaba
Using our previously reported convergent synthetic strategy, secondary amine 6 and aldehyde 9 reacted to give tetracyclic esters 10 and 11, which readily led to pentacyclic lactams 14-16.Selective reduction of these products gave (+/-)-pseudovincadifformine (4), (+/-)-20-epipseudovincadifformine (5), and (+/-)-14-epipseudovincadifformine (20).Aldehyde 23 was also prepared and could be directly used for synthesizing (+/-)-20-epipseudovincadifformine (5).The introduction of the double bond into ring D of the pseudoaspidospermane skeleton was successfully achieved to obtained 21-oxopseudotabersonine (30).
View MoreContact:86-516-66656369
Address:The west road of Huaihai, Xuzhou, China
Shanghai Yuking Water Soluble Material Tech Co., Ltd
Contact:86-21-68286299
Address:4F, 13B, No. 600, South Xinyuan Road 201306, Shanghai, China
Contact:18710867521(wechat)
Address:Rm10516,Galaxy Tech Building #2,No.25 Tangyan Rd,Hi-Tech Zone,Xi'an, China
Shanghai Rich Chemicals Co., Ltd
website:http://www.richchemical.com
Contact:+86-21-20255798
Address:Pudong Shanghai,China
Jinan Kaypharm Chemical Co.,Ltd
Contact:86-0531-86986780
Address:Room101,No189-2,Huayuan Road,Jinan City,Shandong Province
Doi:10.1016/S0040-4020(03)00309-0
(2003)Doi:10.1007/s11172-005-0357-6
(2005)Doi:10.1021/jo01367a003
()Doi:10.1021/jo00863a025
(1976)Doi:10.1021/jm00245a006
(1975)Doi:10.1021/acs.joc.8b01488
(2018)