Potential anti-microbials. I. Synthesis and structure-activity studies of some new thiazolopyrimidine derivatives

Article abstract of DOI:10.1016/0223-5234(93)90001-U

The synthesis of several 2,3-dihydro-3,6-diaryl-5-mercapto-2-thioxothiazolo<4,5-d>pyrimidin-7(6H)-ones and related compounds are discussed.Some members of the series displayed broad in vitro anti-bacterial and anti-fungal activities.Three compounds were screened for anti-HIV potency but were inactive. thiazolo<4,5-d>pyrimidines / anti-bacterial / anti-fungal