Bioorganic and Medicinal Chemistry p. 4645 - 4665 (2004)
Update date:2022-08-04
Topics:
Ochiai, Hiroshi
Ohtani, Tazumi
Ishida, Akiharu
Kusumi, Kensuke
Kato, Masashi
Kohno, Hiroshi
Odagaki, Yoshihiko
Kishikawa, Katuya
Yamamoto, Susumu
Takeda, Hiroshi
Obata, Takaaki
Nakai, Hisao
Toda, Masaaki
Synthesis and biological evaluation of piperidine derivatives is reported. The hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system prompted us to design and synthesize a hydrophilic piperidine
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Doi:10.1016/j.bmcl.2005.03.075
(2005)Doi:10.1016/S0040-4039(02)02289-X
(2002)Doi:10.1021/ic049629j
(2004)Doi:10.1007/s11178-005-0016-2
(2004)Doi:10.1246/bcsj.61.3008
(1988)Doi:10.1007/BF00471296
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