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Difficult macrocyclizations: New strategies for synthesizing highly strained cyclic tetrapeptides

DOI: 10.1021/ol034907o

Source and publish data:

Organic Letters p. 2711 - 2714 (2003)

Update date:2022-08-04

Topics:

Authors:

Meutermans, Wim D. F.Meutermans, Wim D. F.

Bourne, Gregory T.Bourne, Gregory T.

Golding, Simon W.Golding, Simon W.

Horton, Douglas A.Horton, Douglas A.

Campitelli, Marc R.Campitelli, Marc R.

Craik, DavidCraik, David

Scanlon, MartinScanlon, Martin

Smythe, Mark L.Smythe, Mark L.

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Article abstract of DOI:10.1021/ol034907o

(Matrix presented) Cyclic tetrapeptides are an intriguing class of natural products. To synthesize highly strained cyclic tetrapeptides we developed a macrocyclization strategy that involves the inclusion of 2-hydroxy-6-nitrobenzyl (HnB) group at the N-te

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Full text of DOI:10.1021/ol034907o

Products guided by the article

Product name:N-{3-[(2S,5S,8S,11S)-5-Benzyl-11-(4-benzyloxy-benzyl)-4,10-bis-(2-methoxy-6-nitro-benzyl)-8-methyl-3,6,9,12-tetraoxo-1,4,7,10-tetraaza-cyclododec-2-yl]-propyl}-guanidine

Cas No:583051-38-1

583051-38-1

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