Mild Deprotection of Benzyl Ether Protective Groups with Ozone

Article abstract of DOI:10.1055/s-1985-31447

Benzyl ether protective groups are oxidatively removed by ozone under relatively mild conditions.Reaction products are benzoic ester, benzoic acid, and the corresponding alcohol.Subsequent deacylation with sodium methoxide affords a convenient debenzylation technique which has been applied to various O-benzyl protected carbohydrates 1 to afford the deprotected species 2.Glycosides and acetals are unaffected by the treatment.