Molecules p. 8933 - 8948 (2014)
Update date:2022-08-04
Topics:
Swaminathan, Meyyammai
Chee, Chin Fei
Chin, Sek Peng
Buckle, Michael J. C.
Rahman, Noorsaadah Abd.
Doughty, Stephen W.
Chung, Lip Yong
Muscarinic acetylcholine receptor- Active compounds have potential for the treatment of Alzheimer's disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand binding at human cloned M1 muscarinic receptors. Several compounds were found to possess competitive binding affinity (K i = 40-110 μM), comparable to that of acetylcholine (Ki = 59 μM). Despite the fact that these compounds lack a positively-charged ammonium group under physiological conditions, molecular modelling studies suggested that they bind to the orthosteric site of the receptor, mainly through non-polar interactions.
View MoreContact:0792-8228321
Address:10TH Floor No.121 binjiang Road Xunyang District
Contact:+86-25-52346955
Address:199,JIANYE ROAD,NANJING,CHINA
Shandong LuZhou Amino Acid Co., Ltd
Contact:86-539-2218025
Address:yishui economic and technical development zone zhenxing south road
Nanjing lanbai chemical Co.,Ltd.
Contact:+86-25-85499326
Address:Room 908, 9F Taiyue Building,No.285 Heyan Road
Beijing Wisdom Chemicals Co., Ltd.
Contact:+86-10-52350335
Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
Doi:10.1002/hlca.19760590515
(1976)Doi:10.1002/jhet.5570130312
(1976)Doi:10.1007/BF00928094
()Doi:10.1007/BF00742451
()Doi:10.1016/S0960-894X(03)00497-9
(2003)Doi:10.1039/c4sc03804e
(2015)