Molecules p. 8933 - 8948 (2014)
Update date:2022-08-04
Topics:
Swaminathan, Meyyammai
Chee, Chin Fei
Chin, Sek Peng
Buckle, Michael J. C.
Rahman, Noorsaadah Abd.
Doughty, Stephen W.
Chung, Lip Yong
Muscarinic acetylcholine receptor- Active compounds have potential for the treatment of Alzheimer's disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand binding at human cloned M1 muscarinic receptors. Several compounds were found to possess competitive binding affinity (K i = 40-110 μM), comparable to that of acetylcholine (Ki = 59 μM). Despite the fact that these compounds lack a positively-charged ammonium group under physiological conditions, molecular modelling studies suggested that they bind to the orthosteric site of the receptor, mainly through non-polar interactions.
View Morejiangsu senxuan pharmaceutical and chemical co.,ltd
Contact:86-523-87982810
Address:hongqiao industrial zone,taixing,jiangsu china
Jiangsu Hualun Chemical Industry Co., Ltd
website:http://www.hualunchem.com
Contact:+86-0514-86464168 86507985
Address:39# Middle Renmin Road, Dinghuo Town
RongCheng K&S Chemical Co.,Ltd
Contact:0631-7336369
Address:rongcheng ,shandong province china
JIANGSU GRAND XINYI PHARMACEUTICAL CO.,LTD
website:http://www.xypharm.com/
Contact:+86-515-84383317
Address:Chenli Road,Costal Chemical Area Binhai,Yancheng, Jiangsu,China
Contact:+86 512 6287 2180
Address:398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China
Doi:10.1002/hlca.19760590515
(1976)Doi:10.1002/jhet.5570130312
(1976)Doi:10.1007/BF00928094
()Doi:10.1007/BF00742451
()Doi:10.1016/S0960-894X(03)00497-9
(2003)Doi:10.1039/c4sc03804e
(2015)