Journal of Pharmaceutical Sciences p. 1247 - 1251 (1976)
Update date:2022-08-05
Topics:
Foye
Lowe
Lanzillo
A series of N heterocyclic and N heterocyclic alkyl derivatives of bis (2 aminoethyl) disulfide and aminoethanethiosulfuric acid was synthesized as potential antiradiation and anticancer agents. The compounds were prepared by the reactions of the heterocyclic halides with bis (2 aminoethyl) disulfide and aminoethanethiosulfuric acid. A dithio acid derivative, 3,3 dimercapto 2 cyanoacryloylpyrrolidide, was also prepared. Several compounds, including the dithio acid derivative, provided good radiation protection to mice. None of the compounds screened showed appeciable anticancer activities in two leukemia systems.
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