Regioselectivity in the Reformatsky Reaction of 4-Bromocrotonate. Role of the Catalyst and the Solvent in the Normal vs. Abnormal Modes of Addition to Carbonyl Substrates

DOI: 10.1021/jo00184a042

Source and publish data:

Journal of Organic Chemistry p. 1845 - 1848 (1984)

Update date:2022-08-05

Topics:

Authors:

Rice, Leonard E.

Boston, M.Craig

Finklea, Harry O.

Suder, Billy Jo

Frazier, James O.

Hudlicky, Tomas

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Article abstract of DOI:10.1021/jo00184a042

The regioselectivity of addition of the organozinc reagent derived from ethyl 4-bromocrotonate to 10 carbonyl substrates was found to be dependent on the polarity of solvents and the hardness of metal catalysts.

Full text of DOI:10.1021/jo00184a042

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