Journal of Organic Chemistry p. 1757 - 1761 (1990)
Update date:2022-09-26
Topics:
Donnelly, John A.
Farrell, David F.
The cyclization of 2'-aminochalcone (2a) and its side-chain additives has been studied for the development of syntheses of 2-aryl-4-quinolones. 2a and its 2'-acetamido 2b and 2'-benzenesulfonamido 2c derivatives underwent acid- or base-catalyzed cyclization to 1,2,3,4-tetrahydro-4-quinolones.The α,β-dibromides of 2b and 2c cyclized to cis-3-bromo-4-quinolones as did the corresponding α-bromochalcones and the α-bromo-β-methoxy additive of 2c. 2'-Acetamido-α-bromochalcone was cyclized by acid to 1,4-dihydro-2-phenyl-4-quinolone. 2'-Aminochalcone formed a stableepoxide which, with acid, gave cis-3-hydroxy-1,2,3,4-tetrahydro-3-phenyl-4-quinolone. 2'-Aminochalcones 2a-c and their additives, such as dibromide and epoxide, are useful, readily available precursors of various 2-aryl-4-quinolones.
View MoreContact:+86-577-65618087-605
Address:Room 402, Unit 4 Xinhu Bldg. Waitan Ruian City, Zhejiang China.
Zibo Fuxi'er Chemical Co.,Ltd (Shanxian Fuxi'er Chemical Co.,Ltd)
Contact:+86-533-2091422
Address:Eastern 4 on the 3th Road ,Liangxiang Industrial Park, Zibo city ,Shandong,China
Contact:+86-310-7092106
Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
Dayang Chem (Hangzhou) Co.,Ltd.
website:http://www.dycnchem.com
Contact:+86-571-88938639
Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China
KangZhiYuan Pharmaceutical Company Limited
Contact:(Sabrina)86-20-85273232
Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China
Doi:10.1016/S0040-4039(02)00367-2
(2002)Doi:10.1016/S0040-4039(03)01709-X
(2003)Doi:10.1021/jo00431a012
(1977)Doi:10.1016/j.bmc.2018.02.044
(2018)Doi:10.1021/jo01206a001
(1941)Doi:10.1016/S0040-4039(01)93226-5
(1977)