Bioorganic and Medicinal Chemistry Letters p. 5617 - 5621 (2009)
Update date:2022-08-04
Topics:
Marino Jr., Joseph P.
Kallander, Lara S.
Ma, Chun
Oh, Hye-Ja
Lee, Dennis
Gaitanopoulos, Dimitri E.
Krawiec, John A.
Parks, Derek J.
Webb, Christine L.
Ziegler, Kelly
Jaye, Michael
Thompson, Scott K.
The liver X receptors (LXR) play a key role in cholesterol homeostasis and lipid metabolism. SAR studies around tertiary-amine lead molecule 2, an LXR full agonist, revealed that steric and conformational changes to the acetic acid and propanolamine groups produce dramatic effects on agonist efficacy and potency. The new analogs possess good functional activity, demonstrating the ability to upregulate LXR target genes, as well as promote cholesterol efflux in macrophages.
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Doi:10.1021/jo971222r
(1998)Doi:10.1300/J091v14n01_01
(1932)Doi:10.1002/mrc.1666
(2005)Doi:10.1016/S0008-6215(03)00267-2
(2003)Doi:10.1039/j19660001207
(1966)Doi:10.1007/BF00553689
(1980)
