Synthesis and antihypertensive activity of 1 amino 3,4 dihydroisoquinolines

DOI: 10.1021/jm00213a025

Source and publish data:

Journal of Medicinal Chemistry p. 449 - 452 (1977)

Update date:2022-08-05

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Authors:

Diana Diana

Banks Hinshaw

Lape Lape

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Article abstract of DOI:10.1021/jm00213a025

A series of 1-substituted 3,4-dihydroisoquinolines has been synthesized and screened for antihypertensive activity in the renal hypertensive rat. The 1-hydrazino homologue 6 and the corresponding acetaldehyde 25 and acetone 23 hydrazones exhibited good activity but were less effective than hydralazine 7.

Full text of DOI:10.1021/jm00213a025

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