Synthesis and antihypertensive activity of 1 amino 3,4 dihydroisoquinolines

DOI: 10.1021/jm00213a025

Source and publish data:

Journal of Medicinal Chemistry p. 449 - 452 (1977)

Update date:2022-08-05

Topics:

Authors:

Diana Diana

Banks Hinshaw

Lape Lape

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00213a025

A series of 1-substituted 3,4-dihydroisoquinolines has been synthesized and screened for antihypertensive activity in the renal hypertensive rat. The 1-hydrazino homologue 6 and the corresponding acetaldehyde 25 and acetone 23 hydrazones exhibited good activity but were less effective than hydralazine 7.

Full text of DOI:10.1021/jm00213a025

Products guided by the article

Product name:[4-(2-diethylamino-ethoxy)-benzyl]-(3,4-dihydro-isoquinolin-1-yl)-amine

Cas No:61602-50-4

R&D Labs maybe for 61602-50-4

Xiamen Kaijia Imp & Exp Co., Ltd.

Contact:86-592-5101177

Address:Room406 Luhui Building No. 65 Haitian Road Huli Xiamen,China.
Zouping Mingxing Chemical Co.,Ltd.

website:http://www.zoutong.com.cn

Contact:86-543-2240068 2240067

Address:428 Daixi Third Road Zouping County Shandong Province China
lianyungang jinkang pharmaceutical technology co., ltd.

Contact:008651885445517

Address:Jinshan industrial park, Ganyu county, Lianyungang, Jiangsu Province, 222115, China
Beijing Cooperate Pharmaceutical Co.,Ltd

Contact:86-01060279497

Address:No.507,Building 4,Tianhua Street, Biomedicine industrial Base
Hubei Xiangxi Chemical Industry Co.,Ltd

Contact:+86-710-3454830

Address:No.7, Daqing East Road, Xiangfan City, Hubei Province, China

Relevant to this article

Synthesis of 2′-O-[2-[(N,N-dialkylamino)oxy]ethyl]-modified oligonucleotides: Hybridization affinity, resistance to nuclease, and protein binding characteristics

Doi:10.1016/S0040-4020(03)01104-9
(2003)
Galactose oxidase models: Tuning the properties of Cu ^II-phenoxyl radicals

Doi:10.1002/chem.200304880
(2003)
Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity

Doi:10.1021/jm800180e
(2008)
Synthetic study of VLA-4/VCAM-1 inhibitors: Synthesis and structure-activity relationship of piperazinylphenylalanine derivatives

Doi:10.1016/j.bmcl.2007.12.014
(2008)
Fluoroalkyl-Substituted Diazomethanes and Their Application in a General Synthesis of Pyrazoles and Pyrazolines

Doi:10.1002/chem.201601707
(2016)
Doi:10.1021/jm00189a004
(1979)

Article Doi