Synthesis and antihypertensive activity of 1 amino 3,4 dihydroisoquinolines

DOI: 10.1021/jm00213a025

Source and publish data:

Journal of Medicinal Chemistry p. 449 - 452 (1977)

Update date:2022-08-05

Topics:

Authors:

Diana Diana

Banks Hinshaw

Lape Lape

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00213a025

A series of 1-substituted 3,4-dihydroisoquinolines has been synthesized and screened for antihypertensive activity in the renal hypertensive rat. The 1-hydrazino homologue 6 and the corresponding acetaldehyde 25 and acetone 23 hydrazones exhibited good activity but were less effective than hydralazine 7.

Full text of DOI:10.1021/jm00213a025

Products guided by the article

Product name:[4-(2-diethylamino-ethoxy)-benzyl]-(3,4-dihydro-isoquinolin-1-yl)-amine

Cas No:61602-50-4

R&D Labs maybe for 61602-50-4

KAIYUAN CHEMICAL COMPANY LIMITED.

website:http://www.kaiyuanchem.com

Contact:+86-22-59891255/66/77

Address:B-2205, Kuangshi International Building, Yingbin Road, XiangLuo Bay Business District, Binhai New area, Tianjin, China.
Suzhou HeChuang Chemical Co.,Ltd.

Contact:+86-512-88800520

Address:No.9 Guanchao Rd,Changshu Advanced Materials Industy Park
Jinan Kaypharm Chemical Co.,Ltd

Contact:86-0531-86986780

Address:Room101,No189-2,Huayuan Road,Jinan City,Shandong Province
WD Silicone Co., Ltd

Contact:+86-27-87204219, +86-27-87215023

Address:2402, HuiGu Space-time Building, 8 Forest Road, East Lake Hi-Tech Development Zone
GN chemicals co.,ltd

Contact:86 311 85902108 / 85902109

Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China

Relevant to this article

Synthesis of 2′-O-[2-[(N,N-dialkylamino)oxy]ethyl]-modified oligonucleotides: Hybridization affinity, resistance to nuclease, and protein binding characteristics

Doi:10.1016/S0040-4020(03)01104-9
(2003)
Galactose oxidase models: Tuning the properties of Cu ^II-phenoxyl radicals

Doi:10.1002/chem.200304880
(2003)
Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity

Doi:10.1021/jm800180e
(2008)
Synthetic study of VLA-4/VCAM-1 inhibitors: Synthesis and structure-activity relationship of piperazinylphenylalanine derivatives

Doi:10.1016/j.bmcl.2007.12.014
(2008)
Fluoroalkyl-Substituted Diazomethanes and Their Application in a General Synthesis of Pyrazoles and Pyrazolines

Doi:10.1002/chem.201601707
(2016)
Doi:10.1021/jm00189a004
(1979)

Article Doi