Regioselective Synthesis of Acylated N-Heterocycles via the Cascade Reactions of Saturated Cyclic Amines with 2-Oxo-2-arylacetic Acids

Article abstract of DOI:10.1021/acs.joc.8b00805

A highly regioselective and versatile synthesis of acylated N-heterocycles from the cascade reactions of saturated cyclic amines with 2-oxo-2-arylacetic acids is presented. Mechanistically, the formation of the title compounds involves first a C(sp³)-H bond dehydrogenation of cyclic amine to give an enamine intermediate followed by its cross coupling with the acyl species in situ generated through the decarboxylation of 2-oxo-2-arylacetic acid. Interestingly, in this cascade process, the copper catalyst is believed to play a crucial role not only in dehydrogenation but also in the decarboxylation and cross coupling reaction. To the best of our knowledge, this is the first example in which different classes of acylated N-heterocycles were directly prepared from the readily available saturated cyclic amines by using 2-oxo-2-arylacetic acids as the noncorrosive and easy to handle acylating reagents. Compared with literature methods, this new protocol has the advantages such as readily obtainable substrates, broad substrate scope, high efficiency, and good selectivity.

Full text of DOI:10.1021/acs.joc.8b00805

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Article
Regioselective Synthesis of Acylated N-Heterocycles via the Cascade
Reactions of Saturated Cyclic Amines with 2-Oxo-2-arylacetic Acids
Xiaonan Shi, Xi Chen, Muhua Wang, Xinying Zhang, and Xuesen Fan
J. Org. Chem., Just Accepted Manuscript • DOI: 10.1021/acs.joc.8b00805 • Publication Date (Web): 14 May 2018
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Regioselective Synthesis of Acylated N-Heterocycles via the Cascade Reactions of Saturated
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Cyclic Amines with 2-Oxo-2-arylacetic Acids
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Xiaonan Shi, Xi Chen, Muhua Wang, Xinying Zhang,* and Xuesen Fan*
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Henan Key Laboratory of Organic Functional Molecules and Drug Innovation, Collaborative
Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key
Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry
and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China
E-mail: xuesen.fan@htu.cn; xinyingzhang@htu.cn
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Abstract: A highly regioselective and versatile synthesis of acylated N-heterocycles from the
cascade reactions of saturated cyclic amines with 2-oxo-2-arylacetic acids is presented.
Mechanistically, the formation of the title compounds involves firstly a C(sp3)–H bond
dehydrogenation of cyclic amine to give an enamine intermediate followed by its cross coupling
with the acyl species in situ generated through the decarboxylation of 2-oxo-2-arylacetic acid.
Interestingly, in this cascade process the copper catalyst is believed to play a crucial role not only
in dehydrogenation, but also in decarboxylation and cross coupling reaction. To the best of our
knowledge, this is the first example in which different classes of acylated N-heterocycles were
directly prepared from the readily available saturated cyclic amines by using 2-oxo-2-arylacetic
acids as the non-corrosive and easy to handle acylating reagents. Compared with literature
methods, this new protocol has the advantages such as readily obtainable substrates, broad
substrate scope, high efficiency and good selectivity.
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INTRODUCTION
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Acyl N-heterocycles are ubiquitous in natural products and man-made compounds possessing
biological and pharmaceutical activities. They are also important synthons widely used in
synthetic chemistry.1,2 Notwithstanding of their importance, reliable methods for the preparation of
acyl N-heterocycles are still very limited.3-4 In addition, some of these literature methods might be
plagued by poor regioselectivity, expensive catalysts, corrosive reagents, and sophisticated starting
materials. Therefore, the development of new methods for the regioselective synthesis of acyl N-
heterocycles starting from easily obtainable substrates without using toxic and moisture-sensitive
acylation reagents is highly desirable.
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Direct C(sp3)–H bond functionalization of inactivated cyclic amines is flourishing as an atom-
economic synthetic approach to functionalized N-heterocycles since it can eliminate substrate(s)
pre-activation and minimize byproduct(s) production.5 In this regard, we have recently developed
an efficient synthesis of furan-2(5H)-one fused N,O-containing bicyclic compounds via FeCl3-
catalyzed cascade reactions of cyclic amines (1) with 2-oxo-2-arylacetic acids (2) (Scheme 1,
(1)).5g In our following study, we serendipitously found that when FeCl3 was replaced by CuBr2 as
the catalyst, 1 underwent an oxidative acylation process with 2 to afford an acylated heterocycles
rather than the bicyclic products (Scheme 1, (2)). It occurred to us that this is an interesting finding
since although decarboxylative C–H functionalization with carboxylic acids has been developed as
a highly useful tool for C–C bond formation owing to its high efficiency and step-economy,6-8
direct synthesis of acyl heterocycles through the oxidative C(sp3)–H bond acylation of saturated
cyclic amines by using 2-oxo-2-arylacetic acid as easily obtainable, generally stable and
convenient to handle acylation reagents has not been reported previously. Therefore, we set to
have a systematic study on this promising new transformation.
Scheme 1. Functionalizations of Cyclic Amines
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RESULTS AND DISCUSSION
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Our study was commenced by treating a mixture of 1-phenylpiperidine (1a) and 2-oxo-2-
phenylacetic acid (2a) with Cu(OAc)2 and tert-butylperoxide (TBP) in CH3CN at 60 °C for 24 h.
From this reaction, 3-benzoyl-1-phenyltetrahydropyridine (3a) was obtained in 40% yield (Table 1,
entry 1). To improve the efficiency, different copper catalysts such as CuCl2, CuBr2, CuSO4·5H2O,
CuBr and CuI were tried. Among them, CuBr2 was the most efficient (entries 1-6). Following
study on the effect of different oxidants indicated that Ag2CO3 gave a comparable yield of 3a as
that with TBP. However, (NH4)2S2O8 and O2 were much less effective (entries 7-9). It was also
found that when the loading of TBP reduced from 2 equiv to 1 equiv, the yield of 3a diminished
(entry 10). To study the solvent effect, dioxane, DCE, THF and TFE were tried. With these
solvents, the yield of 3a was not improved compared with CH3CN (entries 11-14). Further
screening showed that reaction temperatures higher or lower than 60 °C had an adverse effect on
the efficiency (entries 15-16). It was also observed that in the absence of the copper catalyst or the
oxidant, 3a could not be obtained or was formed only in trace amount (entries 17-18). Notably, the
structure of 3a was confirmed by its single crystal X-ray diffraction analysis.9
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Table 1. Optimization Studies a
Entry
Catalyst
Cu(OAc)2
CuCl2
Oxidant (eq)
TBP(2)
Solvent
CH3CN
CH3CN
CH3CN
CH3CN
CH3CN
CH3CN
CH3CN
CH3CN
CH3CN
CH3CN
dioxane
T/oC
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Yield (%)b
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75
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64
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TBP(2)
3
CuBr2
TBP(2)
4
CuSO4·5H2O
CuBr
TBP(2)
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TBP(2)
6
CuI
TBP(2)
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CuBr2
(NH4)2S2O8(2)
Ag2CO3(2)
O2
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CuBr2
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CuBr2
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CuBr2
TBP(1)
CuBr2
TBP(2)
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CuBr2
CuBr2
CuBr2
CuBr2
CuBr2
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TBP(2)
TBP(2)
TBP(2)
TBP(2)
TBP(2)
TBP(2)
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DCE
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THF
TFE
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CH3CN
CH3CN
CH3CN
CH3CN
72
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-
CuBr2
trace
a Reaction conditions: 0.5 mmol of 1a, 0.6 mmol of 2a, 0.05 mmol of catalyst, 3 mL of solvent, 60 °C, 24 h.
b
Isolated yields.
With the optimum reaction conditions established (Table 1, entry 3), the substrate scope of this
3-acyltetrahydropyridine forming reaction was explored. First, a number of N-phenylpiperidines 1
bearing various functional groups on the phenyl ring were tried by using 2a as a model substrate. It
turned out they took part in this reaction smoothly to give 3a-3k in moderate to good yields (Table
2). Meanwhile, 1 with an ortho, meta, or para-substituent on the phenyl unit afforded the
corresponding products with almost equally good efficiency. In addition, the reactions did not
show an obvious electronic effect in that 1 bearing either electron-donating group(s) or electron-
withdrawing group(s) on the phenyl ring gave their products in good yields. Remarkably,
functional groups such as methyl, ethyl, methoxy, fluoro, bromo and nitro were well tolerated.
Notably, 1-(naphthalene-1-yl)piperidine and 2-(piperidin-1-yl)pyridine could take part in this
reaction to afford 3l and 3m in 60% and 69% yields. In addition to N-aryl piperidines, some N-
alkylpiperidines also reacted with 2a smoothly to give 3n and 3o, albeit the yields were somewhat
lower. Promisingly, the diversity of the substrate structure was further underlined by the successful
participation of 2-methyl-1-phenylpiperidine, 2-ethyl-1-phenylpiperidine and 1,4-diphenyl
piperidine in this reaction to afford 3p-3r. Notably, the reaction of 2-methyl- or 2-ethyl-1-
phenylpiperidine took place regioselectively on the less sterically hindered side to give 3p or 3q
exclusively, and the formation of other possible regioisomer was not observed. Second, we
surveyed the substrate scope and functional group compatibility of 2-oxo-2-arylacetic acids 2. It
was thus found that 2 with either a bromo group attached on the meta-position, or a chloro, methyl,
ester or cyano unit on the para-position of the phenyl unit reacted with 1a smoothly to afford 3s-
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3w in 45%-64% yields. Moreover, heteroaromatic and aliphatic α-keto acids such as 2-oxo-2-
(thiophen-2-yl)acetic acid and 2-oxopropanoic acid could also react with 1a to give 3x and 3y.
Table 2. Substrate Scope for the Synthesis of 3 a,b
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3a, 75%
3b, 66%
3d, 62%
3i, 72%
3e, 64%
3j, 70%
3c, 73%
3f, 69%
3k, 67%
3g, 75%
3l, 60%
3h, 72%
3m, 69%
3r, 59%
3w, 51%
3n, 51%
3s, 63%
3x, 71%
3o, 29%
3t, 64%
3y, 23%
3p, 54%
3u, 57%
3q, 44%
3v, 45%
a Reaction conditions: 0.5 mmol of 1, 0.6 mmol of 2, 0.05 mmol of CuBr2, 1 mmol of TBP, 3 mL of CH3CN,
60 °C, 24 h. b Isolated yields.
Next, given the importance of 1,4-oxazine derivatives,10 we tried to extend the substrate scope
from piperidines 1 to morpholines 4 to establish a novel synthesis of acylated 1,4-oxazines. Thus,
4-phenylmorpholine (4a) was treated with 2a under the optimized conditions. To our delight, the
desired product 5a was obtained in 65% yield (Table 3). Encouraged by this preliminary result, 4-
(3-fluorophenyl)morpholine and 4-(4-methylphenyl)morpholine were tried to react with 2a. From
these reactions, 5b and 5c were obtained in yields of 62% and 51%, respectively. Next, the
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suitability of different 2-oxo-2-arylacetic acids 2 for this reaction was explored. It turned out that
all of them took part in this reaction smoothly to give 5d-5g in good yields. Promisingly, in
addition to morpholines, thiomorpholines were also suitable partners for this reaction to afford
acylated 1,4-thiazine derivatives 5h-5j in moderate yields.
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Table 3. Substrate Scope for the Synthesis of 5 a,b
5a, 65%
5f, 58%
5d, 59%
5i, 51%
5e, 68%
5j, 52%
5b, 62%
5g, 72%
5c, 51%
5h, 62%
a Reaction conditions: 0.5 mmol of 4, 0.6 mmol of 2, 0.05 mmol of CuBr2, 1 mmol of TBP, 3 mL of CH3CN,
60 °C, 24 h. b Isolated yields.
After establishing a novel protocol for the preparation of acylated 6-membered heterocycles, we
then explored the suitability of pyrrolidines as substrates for this reaction to develop an access to
3-acyldihydropyrroles. It is well known that dihydropyrrole is an essential structural fragment
embedded in various natural products and pharmaceuticals. While some elegant methods for the
preparation of dihydropyrroles have been established,11,12 to our knowledge, regioselective
synthesis of 3-acyldihydropyrroles directly from pyrrolidines has not been realized previously.
Thus, 1-phenylpyrrolidine (6a) was treated with 2a under the optimized reaction conditions. From
this reaction, the desired 3-acyldihydropyrrole 7a was obtained in 68% yield(Table 4). Further
study showed that 1-(4-chlorophenyl)pyrrolidine (6b) and 1-(3,5-dimethylphenyl)pyrrolidine (6c)
participated in this reaction smoothly to afford 7b and 7c in yields of 67% and 61%, respectively.
Next, with 6a as a model substrate, the suitability of several 2-oxo-2-arylacetic acids 2 was studied.
It was thus found that 2 with either a methyl or bromo unit attached on the meta-position, or a
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methyl, chloro or bromo unit on the para-position of the phenyl unit reacted with 6a efficiently to
afford 7d-7h in yields ranging from 58%-64%.
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Table 4. Substrate Scope for the Synthesis of 7 and 8 a,b
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7e, 64%
7d, 58%
7a, 68%
7f, 62%
7c, 61%
7h, 60%
7b, 67%
7g, 58%
8b, 47%
8g, 47%
8a, 54%
8f, 60%
8c, 51%
8e, 59%
8d, 57%
a Reaction conditions: 0.5 mmol of 6, 0.6 mmol of 2, 0.05 mmol of CuBr2, 1 mmol of TBP, 3 mL of CH3CN,
60 °C, 24 h. b Isolated yields.
Next, 1-benzylpyrrolidine (6d) as a N-alkyl substituted pyrrolidine was tried to react with 2a. To
our surprise, the expected 3-acyldihydropyrrole 7i was not obtained from this reaction. On the
other hand, 8a, the dehydrogenative counterpart of 7i, was isolated in 54% yield (Scheme 2).
Scheme 2. Reaction of 1-Benzylpyrrolidine
We postulated that this is probably owing to the presence of the electron-donating 1-alkyl
substituent in the in situ formed 7i, which makes 7i have substantially high electron density on the
pyrrole unit to undergo a simultaneous oxidative aromatization to give 8a. In order to get 7i, this
reaction was then carried out in shorter reaction periods and under lower reaction temperatures.
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However, under these reaction conditions 8a was still obtained as a dominating product. Under
this circumstance, we turned our focus from 7 to 8, and explored the substrate generality of this 3-
acylpyrrole forming reaction. We were pleased to find that in addition to 6d, 4-(pyrrolidin-1-
ylmethyl)benzonitrile (6e), 1-methylpyrrolidine (6f) and 3-(pyrrolidin-1-yl)propanenitrile (6g)
could react with different 2-oxo-2-arylacetic acids 2 smoothly to afford the corresponding 3-
acylpyrrole derivatives 8b-8g in yields from 47% to 60% (Table 4).
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Promisingly, further study revealed that this novel protocol for the dehydrogenation and
acylation of saturated cyclic amines could be applied to azepanes 9.13 To be specific, treating 1-
phenylazepane (9a) with 2a under the optimized reaction conditions as described above afforded
acylated azepine 10a in 66% yield (Table 5). Through similar procedure, a series of 3-acylazepine
derivatives 10b-10f were synthesized in moderate to good yields from the corresponding azepanes
and 2-oxo-2-arylacetic acids.
Table 5. Substrate Scope for the Synthesis of 10 a,b
10e, 59%
10f, 61%
10d, 63%
10a, 66%
10c, 65%
10b, 71%
a Reaction conditions: 0.5 mmol of 9, 0.6 mmol of 2, 0.05 mmol of CuBr2, 1 mmol of TBP, 3 mL of CH3CN,
60 °C, 24 h. b Isolated yields.
Based on previous reports5-8 and our own observations, a plausible mechanism accounting for
the formation of 3a was proposed in Scheme 3. Initially, 1a is oxidized by Cu(II)/TBP to give an
iminium intermediate A. Subsequently, an isomerization occurs with A to produce enamine B
through an elimination of a proton. Meanwhile, 2a reacts with Cu(II) to form Cu(II) carboxylate C,
which then undergoes a decarboxylation to afford an acyl Cu(II) species D. Next, a complexation
of the central metal (copper) of D with the electron-rich -carbon of the in situ formed enamine
intermediate B generates a Cu(III) complex E. Isomerization of E gives another Cu(III) complex F.
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Finally, a reductive elimination of F occurs to afford 3a with the release of Cu(I), which is then
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oxidized by TBP to give Cu(II) for the next catalytic cycle.
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Scheme 3. Proposed Mechanism for the Formation of 3a
Finally, to see if this new method is suitable for a large scale synthetic mission, 5 mmol of 1a
was treated with 6 mmol of 2a under the standard reaction conditions. The corresponding reaction
proceeded smoothly to afford 3a in a yield of 54% (Scheme 4).
Scheme 4. Gram-scale Synthesis of 3a
In summary, we have developed a versatile and regioselective synthesis of acylated N-
heterocycles through copper-catalyzed cascade reactions of saturated cyclic tertiary amines with 2-
oxo-2-arylacetic acids. Interestingly, compared with iron,5g copper catalyst has unique capability
to promote the decarboxylative decomposition of glyoxalic acid to give an acyl radical as a key
intermediate and an acylation species. By using this novel protocol, a series of acyl heterocycles
such as tetrahedropyridines, 1,4-oxazines, 1,4-thiazines, dihydropyrroles, pyrroles and azepines
were prepared. Compared with literature methods, the protocol reported herein has notable
features such as good efficiency, easily obtainable substrates, non-noble metal catalyst, and stable,
non-corrosive and easy to handle acylation reagent.
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EXPERIMENTAL SECTION
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I. General methods. All the commercial reagents were used without further purification. Melting
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points were recorded with a micro melting point apparatus and uncorrected. The H NMR spectra
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were recorded at 400 MHz or 600 MHz. The C NMR spectra were recorded at 100 MHz or 150
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MHz. Chemical shifts were expressed in parts per million (δ), and were reported as s (singlet), d
(doublet), t (triplet), q (quartet), quint (quintet), dd (doublet of doublet), m (multiplet), etc. The
coupling constants J were given in Hz. High resolution mass spectra (HRMS) were obtained via
ESI mode by using a MicrOTOF mass spectrometer. The conversion of starting materials was
monitored by thin layer chromatography (TLC) using silica gel plates (silica gel 60 F254 0.25
mm), and components were visualized by observation under UV light (254 and 365 nm).
II. Experimental Procedures
1. Typical Procedure for the Synthesis of 3a
To a reaction tube equipped with a stir bar were added 1-phenylpiperidine (1a, 81 mg, 0.5
mmol), CH3CN (3 mL), 2-oxo-2-phenylacetic acid (2a, 90 mg, 0.6 mmol), CuBr2 (11 mg, 0.05
mmol) and TBP (183 μL, 1 mmol) with stirring. The mixture was stirred under air at 60 °C for 24
h. Afterwards, it was quenched with water (3 mL), and extracted with ethyl acetate (10 mL  3).
The combined organic layers were washed with brine, dried over anhydrous Na2SO4, and
evaporated under reduced pressure. The residue was purified by column chromatography on silica
gel with petroleum ether/ethyl acetate (5:1) as the eluent to give 3a in a yield of 75%. 3b-3t, 5a-5j,
7a-7h, 8a-8f and 10a-10f were obtained in a similar manner.
Phenyl(1-phenyl-1,4,5,6-tetrahydropyridin-3-yl)methanone (3a)
Yellow solid (99 mg, 75%), mp 119-120 °C. 1H NMR (400 MHz, CDCl3) δ: 2.06 (quint, J = 6.0
Hz, 2H), 2.60 (t, J = 6.0 Hz, 2H), 3.69 (t, J = 5.6 Hz, 2H), 6.96 (d, J = 8.0 Hz, 2H), 7.06 (t, J = 7.2
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Hz, 1H), 7.28-7.32 (m, 2H), 7.38-7.43 (m, 3H), 7.53-7.56 (m, 3H). C NMR (100 Hz, CDCl3) δ:
20.0, 21.2, 47.0, 112.8, 118.1, 123.7, 128.1, 128.4, 129.5, 129.9, 140.5, 145.6, 147.0, 194.8.
HRMS calcd for C18H18NO: 264.1383 [M+H]+, found: 264.1383.
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Phenyl(1-(o-tolyl)-1,4,5,6-tetrahydropyridin-3-yl)methanone (3b)
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Yellow solid (91 mg, 66%), mp 93-94 °C. H NMR (400 MHz, CDCl3) δ: 2.05-2.09 (m, 2H),
2.25 (s, 3H), 2.63 (t, J = 6.0 Hz, 2H), 3.53 (t, J = 5.6 Hz, 2H), 7.03 (d, J = 6.8 Hz, 1H), 7.08 (s,
1H), 7.14-7.21 (m, 3H), 7.31-7.34 (m, 3H), 7.48 (d, J = 7.6 Hz, 2H). 13C NMR (150 Hz, CDCl3) δ:
18.2, 19.9, 21.4, 49.5, 110.2, 125.7, 127.0, 127.1, 128.0, 128.2, 129.4, 131.6, 133.4, 140.9, 145.6,
151.0, 194.3. HRMS calcd for C19H19NNaO: 300.1359 [M+Na]+, found: 300.1369.
Phenyl(1-(m-tolyl)-1,4,5,6-tetrahydropyridin-3-yl)methanone (3c)
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Yellow solid (101 mg, 73%), mp 120-121 °C. H NMR (600 MHz, CDCl3) δ: 2.04 (quint, J =
6.0 Hz,, 2H), 2.31 (s, 3H), 2.60 (t, J = 6.6 Hz, 2H), 3.67 (t, J = 6.0 Hz, 2H), 6.76 (d, J = 7.8 Hz,
1H), 6.78 (s, 1H), 6.87 (d, J = 7.8 Hz, 1H), 7.17 (t, J = 7.8 Hz, 1H), 7.37-7.41 (m, 3H), 7.53-7.55
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(m, 3H). C NMR (100 Hz, CDCl3) δ: 20.1, 21.2, 21.6, 47.2, 112.5, 115.4, 119.1, 124.6, 128.1,
128.5, 129.3, 129.9, 139.5, 140.6, 145.7, 147.3, 194.7. HRMS calcd for C19H20NO: 278.1539
[M+H]+, found: 278.1539.
(1-(3-Fluorophenyl)-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3d)
Yellow solid (87 mg, 62%), mp 109-110 °C. 1H NMR (400 MHz, CDCl3) δ: 2.06-2.10 (m, 2H),
2.60 (t, J = 6.0 Hz, 2H), 3.66 (t, J = 5.6 Hz, 2H), 6.66 (d, J = 10.8 Hz, 1H), 6.71-6.76 (m, 2H),
7.23 (t, J = 7.2 Hz,, 1H), 7.40-7.46 (m, 3H), 7.51 (s, 1H), 7.55 (d, J = 8.0 Hz, 2H). 13C NMR (150
Hz, CDCl3) δ: 20.1, 21.2, 46.9, 105.1 (d, 2JC-F = 25.2 Hz), 110.0 (d, 2JC-F = 20.7 Hz), 113.1 (d, 4JC-
F = 3.3 Hz), 113.8, 128.2, 128.4, 130.1, 130.7 (d, 3JC-F = 9.8 Hz), 140.3, 145.8, 147.1 (d, 3JC-F = 9.8
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Hz), 163.5 (d, JC-F = 245.1 Hz), 194.9. HRMS calcd for C18H16FNNaO: 304.1108 [M+Na]+,
found: 304.1137.
(1-(3-Bromophenyl)-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3e)
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Yellow solid (109 mg, 64%), mp 105-106 °C. H NMR (400 MHz, CDCl3) δ: 2.06 (quint, J =
6.0 Hz, 2H), 2.59 (t, J = 6.0 Hz, 2H), 3.65 (t, J = 5.6 Hz, 2H), 6.87 (d, J = 7.2 Hz, 1H), 7.12-7.18
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(m, 3H), 7.40-7.45 (m, 3H), 7.48 (s, 1H), 7.55 (d, J = 7.6 Hz, 2H). C NMR (150 Hz, CDCl3) δ:
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20.1, 21.2, 47.0, 113.9, 116.4, 121.1, 123.3, 126.3, 128.2, 128.4, 130.2, 130.7, 140.2, 145.8, 146.8,
194.9. HRMS calcd for C18H17BrNO: 342.0488 [M+H]+, found: 342.0490.
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(1-(3-Nitrophenyl)-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3f)
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Yellow solid (106 mg, 69%), mp 126-128 °C. H NMR (400 MHz, CDCl3) δ: 2.12 (quint, J =
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6.0 Hz,, 2H), 2.62 (t, J = 6.4 Hz, 2H), 3.74 (t, J = 5.6 Hz, 2H), 7.24 (dd, J1 = 8.0 Hz, J2 = 2.0 Hz,
1H), 7.42-7.48 (m, 4H), 7.56 (s, 1H), 7.58 (dd, J1 = 8.0 Hz, J2 = 1.2 Hz, 2H), 7.82 (t, J = 2.0 Hz,
1H), 7.87 (dd, J1 = 8.0 Hz, J2 = 1.2 Hz, 1H). 13C NMR (100 Hz, CDCl3) δ: 20.1, 21.1, 46.8, 112.1,
115.1, 117.5, 122.8, 128.3, 128.5, 130.4, 130.5, 139.9, 144.7, 146.3, 149.1, 195.0. HRMS calcd for
C18H17N2O3: 309.1234 [M+H]+, found: 309.1251.
(1-(4-Ethylphenyl)-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3g)
Yellow solid (109 mg, 75%), mp 75-76 °C. 1H NMR (400 MHz, CDCl3) δ: 1.18 (t, J = 7.6 Hz,
3H), 2.02 (quint, J = 6.0 Hz,, 2H), 2.54-2.61 (m, 4H), 3.65 (t, J = 5.6 Hz, 2H), 6.88 (d, J = 8.0 Hz,
2H), 7.11 (d, J = 8.4 Hz, 2H), 7.34-7.41 (m, 3H), 7.52-7.54 (m, 3H). 13C NMR (100 Hz, CDCl3) δ:
15.7, 20.0, 21.2, 28.1, 47.3, 112.2, 118.4, 128.1, 128.4, 128.9, 129.7, 140.0, 140.7, 143.6, 147.5,
194.5. HRMS calcd for C20H22NO: 292.1696 [M+H]+, found: 292.1697.
(1-(4-Bromophenyl)-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3h)
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Yellow solid (123 mg, 72%), mp 139-140 °C. H NMR (400 MHz, CDCl3) δ: 2.06 (quint, J =
6.0 Hz, 2H), 2.59 (t, J = 6.0 Hz, 2H), 3.65 (t, J = 5.6 Hz, 2H), 6.83 (d, J = 8.8 Hz, 2H), 7.39-7.44
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(m, 5H), 7.47 (s, 1H), 7.53 (d, J = 8.0 Hz, 2H). C NMR (100 Hz, CDCl3) δ: 20.0, 21.1, 47.0,
113.5, 116.3, 119.5, 128.1, 128.4, 130.0, 132.4, 140.3, 144.6, 146.1, 194.8. HRMS calcd for
C18H17BrNO: 342.0488 [M+H]+, found: 342.0480.
(1-(3,5-Dimethylphenyl)-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3i)
Yellow solid (105 mg, 72%), mp 98-99 °C. 1H NMR (400 MHz, CDCl3) δ: 1.93 (quint, J = 6.0
Hz,, 2H), 2.17 (s, 6H), 2.50 (t, J = 6.0 Hz, 2H), 3.56 (t, J = 5.6 Hz, 2H), 6.49 (s, 2H), 6.62 (s, 1H),
7.27-7.33 (m, 3H), 7.43 (s, 1H), 7.46 (d, J = 7.6 Hz, 2H). 13C NMR (100 Hz, CDCl3) δ: 20.2, 21.3,
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21.5, 47.3, 112.2, 116.4, 125.7, 128.0, 128.5, 129.8, 139.3, 140.7, 145.8, 147.5, 194.6. HRMS
calcd for C20H21NNaO: 314.1515 [M+Na]+, found: 314.1520.
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(1-(3,4-Dimethoxyphenyl)-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3j)
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Yellow solid (113 mg, 70%), mp 125-126 °C. H NMR (400 MHz, CDCl3) δ: 2.04 (quint, J =
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6.0 Hz, 2H), 2.59 (t, J = 6.0 Hz, 2H), 3.66 (t, J = 5.6 Hz, 2H), 3.82 (s, 6H), 6.51-6.53 (m, 2H), 6.78
(d, J = 8.0 Hz, 1H), 7.35-7.40 (m, 3H), 7.45 (s, 1H), 7.53 (d, J = 7.2 Hz, 2H). 13C NMR (100 Hz,
CDCl3) δ: 19.9, 21.2, 47.7, 55.9, 56.2, 103.6, 110.9, 111.7, 111.9, 128.0, 128.3, 129.7, 139.9,
140.7, 146.1, 148.1, 149.6, 194.3. HRMS calcd for C20H22NO3: 324.1594 [M+H]+, found:
324.1590.
(1-Mesityl-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3k)
Yellow solid (102 mg, 67%), mp 82-83 °C. 1H NMR (400 MHz, CDCl3) δ: 2.07 (quint, J = 6.0
Hz, 2H), 2.17 (s, 6H), 2.25 (s, 3H), 2.64 (t, J = 6.0 Hz, 2H), 3.37 (t, J = 5.6 Hz, 2H), 6.87 (s, 2H),
6.91 (s, 1H), 7.26-7.34 (m, 3H), 7.45 (d, J = 7.6 Hz, 2H). 13C NMR (100 Hz, CDCl3) δ: 17.8, 19.7,
20.8, 21.2, 48.4, 108.8, 127.9, 128.2, 129.2, 129.4, 135.5, 137.6, 141.1, 141.5, 151.9, 193.9.
HRMS calcd for C21H24NO: 306.1852 [M+H]+, found: 306.1851.
(1-(Naphthalen-1-yl)-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3l)
Yellow solid (94 mg, 60%), mp 95-96 °C. 1H NMR (600 MHz, CDCl3) δ: 2.18 (br s, 2H), 2.72
(br s, 2H), 3.71 (br s, 2H), 7.23 (d, J = 7.2 Hz, 1H), 7.28-7.30 (m, 4H), 7.42 (t, J = 7.8 Hz, 1H),
7.51-7.58 (m, 4H), 7.75 (d, J = 8.4 Hz, 1H), 7.88 (t, J = 7.2 Hz, 2H). 13C NMR (100 Hz, CDCl3) δ:
20.1, 21.6, 50.5, 110.8, 122.6, 122.8, 125.7, 126.7, 126.9, 127.5, 128.0, 128.3, 128.7, 129.2, 129.5,
134.7, 140.7, 143.4, 151.6, 194.4. HRMS calcd for C22H19NNaO: 336.1359 [M+Na]+, found:
336.1358.
(3,4-Dihydro-2H-[1,2'-bipyridin]-5-yl)(phenyl)methanone (3m)
Yellow solid (91 mg, 69%), mp 115-116 °C. 1H NMR (600 MHz, CDCl3) δ: 2.06-2.07 (m, 2H),
2.61 (t, J = 6.0 Hz, 2H), 3.766-3.773 (m, 2H), 6.80 (d, J = 8.4 Hz, 1H), 6.88 (t, J = 5.4 Hz, 1H),
7.41-7.47 (m, 3H), 7.57-7.61 (m, 3H), 8.227-8.232 (m, 1H), 8.30 (s, 1H). 13C NMR (150 Hz,
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CDCl3) δ: 20.4, 21.1, 44.2, 108.9, 114.5, 117.7, 128.1, 128.7, 130.1, 138.3, 140.3, 143.4, 148.3,
154.4, 195.5. HRMS calcd for C17H17N2O: 265.1335 [M+H]+, found: 265.1334.
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(1-Benzyl-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3n)
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Yellow solid (71 mg, 51%), mp 102-103 °C. 1H NMR (400 MHz, CDCl3) δ: 1.86-1.90 (m, 2H),
2.51 (t, J = 6.0 Hz, 2H), 3.11 (t, J = 6.0 Hz, 2H), 4.26 (s, 2H), 7.15-7.20 (m, 3H), 7.31-7.38 (m,
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6H), 7.47-7.49 (m, 2H). C NMR (150 Hz, CDCl3) δ: 19.5, 21.0, 46.1, 60.2, 108.2, 127.3, 127.9,
128.1, 128.3, 128.9, 129.3, 136.2, 141.1, 152.4, 193.3. HRMS calcd for C19H20NO: 278.1539
[M+H]+, found: 278.1529.
(1-Ethyl-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3o)
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Yellow solid (31 mg, 29%), mp 97-98 °C. H NMR (400 MHz, CDCl3) δ: 1.14 (t, J = 7.6 Hz,
3H), 1.90 (quint, J = 6.0 Hz, 2H), 2.50 (t, J = 6.0 Hz, 2H), 3.12-3.20 (m, 4H), 7.03 (s, 1H), 7.34-
7.39 (m, 3H), 7.44-7.47 (m, 2H). 13C NMR (150 Hz, CDCl3) δ: 13.8, 19.6, 21.1, 45.9, 51.0, 107.6,
127.9, 128.3, 129.1, 141.4, 151.8, 192.9. HRMS calcd for C14H18NO: 216.1383 [M+H]+, found:
216.1381.
(6-Methyl-1-phenyl-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3p)
Yellow solid (75 mg, 54%), mp 102-104 °C. 1H NMR (600 MHz, CDCl3) δ: 1.29 (d, J = 6.6 Hz,
3H), 1.90-1.98 (m, 2H), 2.42-2.47 (m, 1H), 2.80-2.83 (m, 1H), 4.21 (s, 1H), 7.01 (d, J = 7.8 Hz,
2H), 7.07 (t, J = 7.8 Hz, 1H), 7.30 (t, J = 7.2 Hz, 2H), 7.38-7.42 (m, 3H), 7.47 (s, 1H), 7.54 (d, J =
6.6 Hz, 2H). 13C NMR (100 Hz, CDCl3) δ: 16.2, 18.0, 26.8, 51.5, 112.2, 119.0, 123.9, 128.1, 128.4,
129.6, 129.8, 140.6, 144.9, 146.0, 194.8. HRMS calcd for C19H20NO: 278.1539 [M+H]+, found:
278.1536.
(6-Ethyl-1-phenyl-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3q)
Syrup (64 mg, 44%). 1H NMR (400 MHz, CDCl3) δ: 0.95 (t, J = 7.6 Hz, 3H), 1.60-1.72 (m, 2H),
1.75-1.84 (m, 1H), 2.15-2.21 (m, 1H), 2.31-2.40 (m, 1H), 2.76-2.82 (m, 1H), 3.92-3.95 (m, 1H),
6.99 (d, J = 7.6 Hz, 2H), 7.07 (t, J = 7.6 Hz, 1H), 7.28-7.32 (m, 2H), 7.36-7.44 (m, 3H), 7.48 (s,
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1H), 7.52-7.55 (m, 2H). C NMR (150 Hz, CDCl3) δ: 10.3, 16.2, 22.7, 24.0, 57.5, 112.5, 119.2,
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123.9, 128.1, 128.4, 129.6, 129.8, 140.7, 145.2, 146.2, 194.7. HRMS calcd for C20H21NNaO:
314.1515 [M+Na]+, found: 314.1516.
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(1,4-Diphenyl-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone (3r)
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2.17-2.25 (m, 1H), 3.44-3.51 (m, 1H), 3.58-3.61 (m, 1H), 4.44 (d, J = 3.6 Hz, 1H), 7.00 (d, J = 8.0
Hz, 2H), 7.08 (t, J = 7.6 Hz, 1H), 7.17-7.21 (m, 1H), 7.27-7.33 (m, 6H), 7.37-7.45 (m, 3H), 7.59
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(dd, J1 = 7.6 Hz, J2 = 1.6 Hz, 2H), 7.83 (s, 1H). C NMR (150 Hz, CDCl3) δ: 29.3, 35.0, 42.9,
113.9, 118.2, 123.9, 126.3, 127.8, 128.1, 128.4, 128.6, 129.6, 130.0, 140.6, 145.3, 145.5, 147.0,
193.9. HRMS calcd for C24H22NO: 340.1696 [M+H]+, found: 340.1696.
(3-Bromophenyl)(1-phenyl-1,4,5,6-tetrahydropyridin-3-yl)methanone (3s)
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Yellow solid (107 mg, 63%), mp 113-114 °C. H NMR (400 MHz, CDCl3) δ: 2.06 (quint, J =
6.0 Hz, 2H), 2.59 (t, J = 6.0 Hz, 2H), 3.70 (t, J = 5.6 Hz, 2H), 6.99 (d, J = 8.4 Hz, 2H), 7.09 (t, J =
7.2 Hz, 1H), 7.26 (t, J = 7.6 Hz, 1H), 7.33 (t, J = 7.2 Hz, 2H), 7.44-7.46 (m, 1H), 7.50 (s, 1H), 7.55
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(dd, J1 = 8.0 Hz, J2 = 0.8 Hz, 1H), 7.69 (s, 1H). C NMR (100 Hz, CDCl3) δ: 19.9, 21.1, 47.2,
112.5, 118.4, 122.4, 124.1, 126.8, 129.60, 129.65, 131.4, 132.7, 142.5, 145.5, 147.4, 192.7. HRMS
calcd for C18H17BrNO: 342.0488 [M+H]+, found: 342.0498.
(4-Chlorophenyl)(1-phenyl-1,4,5,6-tetrahydropyridin-3-yl)methanone (3t)
Yellow solid (95 mg, 64%), mp 126-127 °C. 1H NMR (400 MHz, CDCl3) δ: 2.07 (quint, J = 6.0
Hz, 2H), 2.60 (t, J = 6.0 Hz, 2H), 3.71 (t, J = 5.6 Hz, 2H), 6.99 (d, J = 8.0 Hz, 2H), 7.10 (t, J = 7.6
Hz, 1H), 7.33 (t, J = 8.0 Hz, 2H), 7.38 (d, J = 7.6 Hz, 2H), 7.50-7.51 (m, 3H). 13C NMR (150 Hz,
CDCl3) δ: 20.0, 21.1, 47.1, 112.7, 118.2, 123.9, 128.4, 129.6, 129.8, 135.9, 138.9, 145.6, 146.9,
193.2. HRMS calcd for C18H16ClNNaO: 320.0813 [M+Na]+, found: 320.0831.
(1-Phenyl-1,4,5,6-tetrahydropyridin-3-yl)(p-tolyl)methanone (3u)
Yellow solid (79 mg, 57%), mp 100-101 °C. 1H NMR (400 MHz, CDCl3) δ: 1.99 (quint, J = 6.0
Hz, 2H), 2.31 (s, 3H), 2.53 (t, J = 6.0 Hz, 2H), 3.62 (t, J = 5.6 Hz, 2H), 6.91 (d, J = 8.0 Hz, 2H),
6.99 (t, J = 7.6 Hz, 1H), 7.13 (t, J = 8.0 Hz, 2H), 7.24 (t, J = 7.6 Hz, 2H), 7.39 (d, J = 7.6 Hz, 2H),
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7.50 (s, 1H). 13C NMR (100 Hz, CDCl3) δ: 19.1, 20.2, 20.4, 46.0, 111.9, 117.1, 122.4, 127.5, 127.7,
128.5, 136.7, 139.0, 144.7, 145.4, 193.6. HRMS calcd for C19H20NO: 278.1539 [M+H]+, found:
278.1530.
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Methyl 4-(1-phenyl-1,4,5,6-tetrahydropyridine-3-carbonyl)benzoate (3v)
Yellow solid (72 mg, 45%), mp 132-133 °C . 1H NMR (400 MHz, CDCl3) δ: 2.07 (quint, J = 6.4
Hz, 2H), 2.61 (t, J = 6.4 Hz, 2H), 3.71 (t, J = 5.6 Hz, 2H), 3.93 (s, 3H), 6.96 (d, J = 7.6 Hz, 2H),
7.08 (t, J = 7.6 Hz, 1H), 7.31 (t, J = 8.0 Hz, 2H), 7.47 (s, 1H), 7.59 (d, J = 8.4 Hz, 2H), 8.07 (d, J =
8.0 Hz, 2H). 13C NMR (150 Hz, CDCl3) δ: 19.9, 21.1, 47.2, 52.3, 112.7, 118.3, 124.1, 128.3, 129.4,
129.6, 131.1, 144.8, 145.5, 147.6, 166.7, 193.6. HRMS calcd for C20H19NNaO3: 344.1257
[M+Na]+, found: 344.1263.
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4-(1-Phenyl-1,4,5,6-tetrahydropyridine-3-carbonyl)benzonitrile (3w)
Yellow solid (73 mg, 51%), mp 127-129 °C . 1H NMR (400 MHz, CDCl3) δ: 2.07 (quint, J = 6.0
Hz, 2H), 2.60 (t, J = 6.0 Hz, 2H), 3.72 (t, J = 5.6 Hz, 2H), 6.97-6.99 (m, 2H), 7.11 (t, J = 7.2 Hz,
1H), 7.31-7.35 (m, 2H), 7.41 (s, 1H), 7.61 (dd, J1 = 6.8 Hz, J2 = 1.6 Hz, 2H), 7.69 (dd, J1 = 6.8 Hz,
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J2 = 1.6 Hz, 2H). C NMR (150 Hz, CDCl3) δ: 19.8, 21.0, 47.4, 112.4, 113.3, 118.47, 118.53,
124.4, 128.9, 129.7, 132.1, 144.9, 145.4, 147.7, 192.2. HRMS calcd for C19H16N2NaO: 311.1155
[M+Na]+, found: 311.1161.
(1-Phenyl-1,4,5,6-tetrahydropyridin-3-yl)(thiophen-2-yl)methanone (3x)
Yellow solid (95 mg, 71%), mp 134-135 °C . 1H NMR (400 MHz, CDCl3) δ: 1.98 (quint, J = 6.4
Hz, 2H), 2.54 (t, J = 6.4 Hz, 2H), 3.63 (t, J = 5.6 Hz, 2H), 6.98-7.04 (m, 4H), 7.27 (td, J1 = 7.6 Hz,
J2 = 2.0 Hz, 2H), 7.38 (dd, J1 = 7.6 Hz, J2 = 1.2 Hz, 1H), 7.41 (dd, J1 = 5.2 Hz, J2 = 1.2 Hz, 1H),
7.91 (s, 1H). 13C NMR (100 Hz, CDCl3) δ: 20.5, 21.2, 47.0, 112.8, 118.2, 123.7, 127.0, 129.6,
129.8, 129.9, 144.3, 145.2, 145.7, 185.1. HRMS calcd for C16H16NOS: 270.0947 [M+H]+, found:
270.0965.
1-(1-Phenyl-1,4,5,6-tetrahydropyridin-3-yl)ethanone (3y)
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Syrup (23 mg, 23%). 1H NMR (400 MHz, CDCl3) δ: 1.89 (quint, J = 6.4 Hz, 2H), 2.17 (s, 3H),
2.33 (t, J = 6.4 Hz, 2H), 3.54 (t, J = 6.0 Hz, 2H), 7.00-7.04 (m, 3H), 7.27-7.31 (m, 2H), 7.69 (s,
1H). 13C NMR (150 Hz, CDCl3) δ: 19.8, 21.2, 24.3, 46.7, 113.5, 118.1, 123.5, 129.5, 142.8, 145.9,
195.0. HRMS calcd for C13H16NO: 202.1226 [M+H]+, found: 202.1251.
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Phenyl(4-phenyl-3,4-dihydro-2H-1,4-oxazin-6-yl)methanone (5a)
Yellow solid (86 mg, 65%), mp 112-113 °C. 1H NMR (400 MHz, CDCl3) δ: 3.80 (t, J = 4.0 Hz,
2H), 4.33 (t, J = 4.0 Hz, 2H), 6.97 (d, J = 8.0 Hz, 2H), 7.06 (t, J = 7.2 Hz, 1H), 7.27 (s, 1H), 7.34
(t, J = 8.0 Hz, 2H), 7.42 (t, J = 7.2 Hz, 2H), 7.49 (t, J = 7.2 Hz, 1H), 7.69 (d, J = 7.6 Hz, 2H). 13C
NMR (150 Hz, CDCl3) δ: 45.3, 63.4, 116.6, 123.2, 127.8, 128.2, 128.8, 129.7, 130.9, 135.2, 138.7,
143.9, 187.9. HRMS calcd for C17H16NO2: 266.1176 [M+H]+, found: 266.1177.
(4-(3-Fluorophenyl)-3,4-dihydro-2H-1,4-oxazin-6-yl)(phenyl)methanone (5b)
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Yellow solid (88 mg, 62%), mp 100-101 °C. H NMR (600 MHz, CDCl3) δ: 3.76 (br s, 2H),
4.33 (br s, 2H), 6.65 (d, J = 10.8 Hz, 1H), 6.73-6.74 (m, 2H), 7.22 (s, 1H), 7.28 (t, J = 7.8 Hz, 1H),
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7.43 (t, J = 7.2 Hz, 2H), 7.51 (t, J = 7.2 Hz, 1H), 7.70 (d, J = 7.2 Hz, 2H). C NMR (150 Hz,
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CDCl3) δ: 45.1, 63.4, 103.6 (d, JC-F = 25.1 Hz), 109.6 (d, JC-F = 21.8 Hz), 111.6 (d, JC-F = 3.3
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Hz), 126.3, 128.2, 128.8, 131.0 (d, JC-F = 9.8 Hz), 131.2, 135.6, 138.4, 145.3 (d, JC-F = 9.9 Hz),
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163.6 (d, JC-F = 245.1 Hz), 188.0. HRMS calcd for C17H15FNO2: 284.1081 [M+H]+, found:
284.1098.
Phenyl(4-(p-tolyl)-3,4-dihydro-2H-1,4-oxazin-6-yl)methanone (5c)
Yellow solid (71 mg, 51%), mp 93-94 °C. 1H NMR (600 MHz, CDCl3) δ: 2.30 (s, 3H), 3.78 (br
s, 2H), 4.31 (br s, 2H), 6.87 (d, J = 7.2 Hz, 2H), 7.13 (d, J = 7.2 Hz, 2H), 7.23 (s, 1H), 7.41 (t, J =
7.2 Hz, 2H), 7.47 (t, J = 7.2 Hz, 1H), 7.68 (d, J = 7.8 Hz, 2H). 13C NMR (150 Hz, CDCl3) δ: 20.6,
45.5, 63.3, 116.8, 128.1, 128.6, 128.8, 130.2, 130.8, 133.1, 134.8, 138.8, 141.7, 187.6. HRMS
calcd for C18H18NO2: 280.1332 [M+H]+, found: 280.1332.
(3-Chlorophenyl)(4-phenyl-3,4-dihydro-2H-1,4-oxazin-6-yl)methanone (5d)
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Yellow solid (88 mg, 59%), mp 111-112 °C. 1H NMR (400 MHz, CDCl3) δ: 3.80 (t, J = 4.4 Hz,
2H), 4.31 (t, J = 4.4 Hz, 2H), 6.99 (d, J = 8.0 Hz, 2H), 7.08 (t, J = 7.2 Hz, 1H), 7.28 (s, 1H), 7.33-
7.37 (m, 3H), 7.44 (d, J = 7.6 Hz, 1H), 7.57 (d, J = 7.6 Hz, 1H), 7.69 (s, 1H). 13C NMR (150 Hz,
CDCl3) δ: 45.4, 63.3, 116.8, 123.5, 126.9, 128.1, 128.9, 129.5, 129.8, 130.9, 134.3, 134.9, 140.3,
143.8, 185.9. HRMS calcd for C17H15ClNO2: 300.0786 [M+H]+, found: 300.0795.
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(4-Phenyl-3,4-dihydro-2H-1,4-oxazin-6-yl)(p-tolyl)methanone (5e)
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Yellow solid (95 mg, 68%), mp 133-135 °C. H NMR (400 MHz, CDCl3) δ: 2.29 (s, 3H), 3.67
(t, J = 4.0 Hz, 2H), 4.20 (t, J = 4.0 Hz, 2H), 6.86 (d, J = 8.0 Hz, 2H), 6.94 (t, J = 7.2 Hz, 1H), 7.11
(d, J = 7.6 Hz, 2H), 7.18 (s, 1H), 7.22 (t, J = 8.0 Hz, 2H), 7.51 (d, J = 7.6 Hz, 2H). 13C NMR (150
Hz, CDCl3) δ: 20.5, 44.1, 62.3, 115.4, 121.9, 126.2, 127.76, 127.84, 128.6, 134.1, 134.8, 140.3,
142.8, 186.6. HRMS calcd for C18H18NO2: 280.1332 [M+H]+, found: 280.1342.
(4-Fluorophenyl)(4-phenyl-3,4-dihydro-2H-1,4-oxazin-6-yl)methanone (5f)
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Yellow solid (82 mg, 58%), mp 76-77 °C. H NMR (400 MHz, CDCl3) δ: 3.74 (t, J = 4.0 Hz,
2H), 4.25 (t, J = 4.0 Hz, 2H), 6.92 (d, J = 8.4 Hz, 2H), 6.99-7.05 (m, 3H), 7.21 (s, 1H), 7.28 (t, J =
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7.6 Hz, 2H), 7.65-7.69 (m, 2H). C NMR (100 Hz, CDCl3) δ: 45.3, 63.3, 115.2 (d, JC-F = 21.1
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Hz), 116.5, 123.3, 127.3, 129.8, 131.2 (d, JC-F = 8.7 Hz), 134.8, 135.1, 143.9, 164.4 (d, JC-F
250.2 Hz), 186.3. HRMS calcd for C17H15FNO2: 284.1081 [M+H]+, found: 284.1093.
(4-Chlorophenyl)(4-(p-tolyl)-3,4-dihydro-2H-1,4-oxazin-6-yl)methanone (5g)
=
Yellow solid (112 mg, 72%), mp 95-96 °C. 1H NMR (400 MHz, CDCl3) δ: 2.25 (s, 3H), 3.72 (t,
J = 4.0 Hz, 2H), 4.24 (t, J = 4.0 Hz, 2H), 6.82 (d, J = 8.8 Hz, 2H), 7.08 (d, J = 8.0 Hz, 2H), 7.16 (s,
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1H), 7.32 (d, J = 8.4 Hz, 2H), 7.58 (d, J = 8.0 Hz, 2H). C NMR (150 Hz, CDCl3) δ: 20.6, 45.6,
63.2, 116.8, 128.2, 128.4, 130.2, 130.3, 133.3, 134.7, 137.0, 137.1, 141.7, 186.1. HRMS calcd for
C18H17ClNO2: 314.0942 [M+H]+, found: 314.0956.
Phenyl(4-phenyl-3,4-dihydro-2H-1,4-thiazin-6-yl)methanone (5h)
Yellow solid (87 mg, 62%), mp 144-145 °C. 1H NMR (600 MHz, CDCl3) δ: 3.13 (t, J = 4.8 Hz,
2H), 4.06 (t, J = 5.4 Hz, 2H), 7.00 (d, J = 7.8 Hz, 2H), 7.13 (t, J = 7.2 Hz, 1H), 7.33 (t, J = 7.2 Hz,
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NMR (100 Hz, CDCl3) δ: 24.0, 48.7, 108.7, 119.7, 124.8, 128.3, 128.4, 129.7, 130.4, 139.1, 143.2,
146.0, 191.8. HRMS calcd for C17H16NOS: 282.0947 [M+H]+, found: 282.0953.
(4-Phenyl-3,4-dihydro-2H-1,4-thiazin-6-yl)(p-tolyl)methanone (5i)
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Yellow solid (75 mg, 51%), mp 103-104 °C. 1H NMR (600 MHz, CDCl3) δ: 2.31 (s, 3H), 3.05-
3.06 (m, 2H), 3.98-3.99 (m, 2H), 6.93 (d, J = 7.8 Hz, 2H), 7.05 (t, J = 7.8 Hz, 1H), 7.13 (d, J = 7.8
Hz, 2H), 7.26 (t, J = 8.4 Hz, 2H), 7.42 (d, J = 8.4 Hz, 2H), 7.60 (s, 1H). 13C NMR (150 Hz,
CDCl3) δ: 21.5, 24.1, 48.6, 108.7, 119.7, 124.6, 128.6, 128.9, 129.7, 136.2, 140.8, 142.7, 146.1,
191.8. HRMS calcd for C18H18NOS: 296.1104 [M+H]+, found: 296.1104.
(4-Bromophenyl)(4-phenyl-3,4-dihydro-2H-1,4-thiazin-6-yl)methanone (5j)
Yellow solid (93 mg, 52%), mp 112-113 °C. 1H NMR (400 MHz, CDCl3) δ: 3.13 (t, J = 4.8 Hz,
2H), 4.07 (t, J = 5.2 Hz, 2H), 7.01 (d, J = 8.0 Hz, 2H), 7.16 (t, J = 7.2 Hz, 1H), 7.36 (t, J = 7.6 Hz,
2H), 7.45 (d, J = 8.4 Hz, 2H), 7.55 (d, J = 8.0 Hz, 2H), 7.59 (s, 1H). 13C NMR (100 Hz, CDCl3) δ:
24.0, 48.8, 108.4, 119.8, 125.0, 125.1, 129.8, 130.1, 131.5, 137.8, 143.2, 145.9, 190.5. HRMS
calcd for C17H15BrNOS: 360.0052 [M+H]+, found: 360.0055.
Phenyl(1-phenyl-4,5-dihydro-1H-pyrrol-3-yl)methanone (7a)
Syrup (85 mg, 68%). 1H NMR (400 MHz, CDCl3) δ: 3.17 (t, J = 10.0 Hz, 2H), 4.05 (t, J = 10.0
Hz, 2H), 6.91 (d, J = 7.6 Hz, 2H), 7.00 (t, J = 7.2 Hz, 1H), 7.29-7.33 (m, 2H), 7.42-7.49 (m, 3H),
7.53 (s, 1H), 7.64-7.66 (m, 2H). 13C NMR (100 Hz, CDCl3) δ: 27.2, 49.9, 114.6, 118.3, 122.2,
128.0, 128.4, 129.7, 130.5, 140.9, 141.0, 146.2, 190.4. HRMS calcd for C17H15NNaO: 272.1046
[M+Na]+, found: 272.1058.
(1-(4-Chlorophenyl)-4,5-dihydro-1H-pyrrol-3-yl)(phenyl)methanone (7b)
Yellow solid (95 mg, 67%), mp 144-145 °C. 1H NMR (600 MHz, CDCl3) δ: 3.07 (t, J = 9.6 Hz,
2H), 3.92 (t, J = 9.6 Hz, 2H), 6.72-6.74 (m, 2H), 7.16-7.18 (m, 2H), 7.35-7.37 (m, 3H), 7.40-7.42
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(m, 1H), 7.56-7.57 (m, 2H). C NMR (150 Hz, CDCl3) δ: 27.3, 50.0, 115.7, 118.9, 127.1, 127.9,
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128.4, 129.6, 130.7, 139.6, 140.8, 145.4, 190.4. HRMS calcd for C17H15ClNO: 284.0837 [M+H]+,
found: 284.0837.
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(1-(3,5-Dimethylphenyl)-4,5-dihydro-1H-pyrrol-3-yl)(phenyl)methanone (7c)
Yellow solid (84 mg, 61%), mp 88-89 °C. 1H NMR (400 MHz, CDCl3) δ: 2.29 (s, 6H), 3.14 (t, J
= 10.0 Hz, 2H), 4.02 (t, J = 9.6 Hz, 2H), 6.53 (s, 2H), 6.65 (s, 1H), 7.44-7.50 (m, 4H), 7.66 (dd, J1
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= 7.6 Hz, J2 = 1.2 Hz, 2H). C NMR (100 Hz, CDCl3) δ: 21.5, 27.1, 50.0, 112.7, 117.9, 124.2,
128.0, 128.3, 130.4, 139.4, 140.9, 141.1, 146.5, 190.2. HRMS calcd for C19H20NO: 278.1539
[M+H]+, found: 278.1545.
(1-Phenyl-4,5-dihydro-1H-pyrrol-3-yl)(m-tolyl)methanone (7d)
Syrup (76 mg, 58%). 1H NMR (600 MHz, CDCl3) δ: 2.40 (s, 3H), 3.14 (t, J = 9.6 Hz, 2H), 4.02
(t, J = 9.6 Hz, 2H), 6.89 (d, J = 7.8 Hz, 2H), 6.99 (t, J = 7.2 Hz, 1H), 7.28-7.32 (m, 4H), 7.43 (d, J
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= 6.6 Hz, 1H), 7.47 (s, 1H), 7.51 (s, 1H). C NMR (100 Hz, CDCl3) δ: 21.5, 27.2, 49.9, 114.6,
118.3, 122.2, 125.1, 128.1, 128.6, 129.7, 131.3, 138.2, 140.9, 141.0, 146.2, 190.7. HRMS calcd for
C18H18NO: 264.1383 [M+H]+, found: 264.1382.
(3-Bromophenyl)(1-phenyl-4,5-dihydro-1H-pyrrol-3-yl)methanone (7e)
Yellow solid (105 mg, 64%), mp 85-86 °C. 1H NMR (600 MHz, CDCl3) δ: 3.14 (t, J = 9.6 Hz,
2H), 4.05 (t, J = 9.6 Hz, 2H), 6.92 (d, J = 7.2 Hz, 2H), 7.02 (t, J = 7.2 Hz, 1H), 7.29-7.33 (m, 3H),
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7.49 (s, 1H), 7.56 (d, J = 7.2 Hz, 1H), 7.60 (d, J = 7.8 Hz, 1H), 7.78 (s, 1H). C NMR (150 Hz,
CDCl3) δ: 27.1, 50.1, 114.9, 117.9, 122.6, 122.7, 126.5, 129.7, 130.0, 130.9, 133.4, 140.6, 142.8,
146.7, 188.3. HRMS calcd for C17H15BrNO: 328.0332 [M+H]+, found: 328.0340.
(1-Phenyl-4,5-dihydro-1H-pyrrol-3-yl)(p-tolyl)methanone (7f)
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Syrup (82 mg, 62%). H NMR (400 MHz, CDCl3) δ: 2.42 (s, 3H), 3.16 (t, J = 10.0 Hz, 2H),
4.04 (t, J = 9.6 Hz, 2H), 6.91 (d, J = 8.0 Hz, 2H), 7.00 (t, J = 7.6 Hz, 1H), 7.25 (d, J = 7.6 Hz, 2H),
7.29-7.33 (m, 2H), 7.54(s, 1H), 7.57 (d, J = 8.4 Hz, 2H). 13C NMR (100 Hz, CDCl3) δ: 21.5, 27.3,
49.8, 114.6, 118.3, 122.1, 128.1, 129.0, 129.6, 138.2, 140.9, 141.0, 145.9, 190.4. HRMS calcd for
C18H18NO: 264.1383 [M+H]+, found: 264.1386.
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(4-Chlorophenyl)(1-phenyl-4,5-dihydro-1H-pyrrol-3-yl)methanone (7g)
Syrup (82 mg, 58%). 1H NMR (600 MHz, CDCl3) δ: 3.14 (t, J = 9.6 Hz, 2H), 4.04 (t, J = 9.6 Hz,
2H), 6.91 (d, J = 7.2 Hz, 2H), 7.01 (t, J = 7.2 Hz, 1H), 7.31 (t, J = 7.2 Hz, 2H), 7.40 (d, J = 7.2 Hz,
2H), 7.49 (s, 1H), 7.59 (d, J = 7.2 Hz, 2H). 13C NMR (100 Hz, CDCl3) δ: 27.1, 50.0, 114.8, 118.0,
122.5, 128.6, 129.4, 129.7, 136.6, 139.2, 140.7, 146.4, 188.8. HRMS calcd for C17H15ClNO:
284.0837 [M+H]+, found: 284.0837.
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(4-Bromophenyl)(1-phenyl-4,5-dihydro-1H-pyrrol-3-yl)methanone (7h)
Syrup (98 mg, 60%). 1H NMR (600 MHz, CDCl3) δ: 3.13 (t, J = 9.6 Hz, 2H), 4.03 (t, J = 9.6 Hz,
2H), 6.91 (d, J = 7.8 Hz, 2H), 7.01 (t, J = 7.2 Hz, 1H), 7.31 (t, J = 7.8 Hz, 2H), 7.49 (s, 1H), 7.52
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(d, J = 7.8 Hz, 2H), 7.56 (d, J = 7.2 Hz, 2H). C NMR (100 Hz, CDCl3) δ: 27.1, 49.9, 114.8,
118.0, 122.5, 124.9, 129.6, 129.7, 131.5, 139.7, 140.7, 146.2, 188.9. HRMS calcd for C17H15BrNO:
328.0332 [M+H]+, found: 328.0331.
(1-Benzyl-1H-pyrrol-3-yl)(phenyl)methanone (8a)14
Syrup (70 mg, 54%). 1H NMR (400 MHz, CDCl3) δ: 5.06 (s, 2H), 6.68 (t, J = 2.8 Hz, 1H), 6.72
(t, J = 2.8 Hz, 1H), 7.12-7.14 (m, 2H), 7.26-7.35 (m, 4H), 7.42 (t, J = 8.0 Hz, 2H), 7.48-7.51 (m,
1H), 7.80-7.82 (m, 2H). 13C NMR (100 Hz, CDCl3) δ: 53.9, 111.4, 122.8, 124.8, 127.3, 128.2,
128.4, 128.9, 129.0, 131.4, 136.6, 140.1, 190.7. HRMS calcd for C18H15NNaO: 284.1046 [M+Na]+,
found: 284.1048.
(1-Benzyl-1H-pyrrol-3-yl)(3-(trifluoromethyl)phenyl)methanone (8b)
Syrup (77 mg, 47%). 1H NMR (400 MHz, CDCl3) δ: 5.11 (s, 2H), 6.68-6.70 (m, 1H), 6.72-6.74
(m, 1H), 7.16-7.18 (m, 2H), 7.26-7.27 (m, 1H), 7.32-7.38 (m, 3H), 7.58 (t, J = 7.6 Hz, 1H), 7.77 (d,
J = 8.0 Hz, 1H), 8.00 (d, J = 7.2 Hz, 1H), 8.07 (s, 1H). 13C NMR (100 Hz, CDCl3) δ: 54.0, 111.4,
123.1, 123.9 (q, 1JC-F = 270.1 Hz), 124.2, 125.7 (q, 3JC-F = 4.3 Hz), 127.4, 127.8 (q, 3JC-F = 3.6 Hz),
128.3, 128.4, 128.8, 129.1, 130.7 (q, 2JC-F = 32.7 Hz), 132.1, 136.2, 140.6, 189.0. HRMS calcd for
C19H15F3NO: 330.1100 [M+H]+, found: 330.1113.
(1-Benzyl-1H-pyrrol-3-yl)(4-chlorophenyl)methanone (8c)
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Syrup (75 mg, 51%). 1H NMR (400 MHz, CDCl3) δ: 5.09 (s, 2H), 6.68-6.71 (m, 2H), 7.15-7.17
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(m, 2H), 7.26-7.27 (m, 1H), 7.32-7.38 (m, 3H), 7.40-7.43 (m, 2H), 7.75-7.79 (m, 2H). C NMR
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(100 Hz, CDCl3) δ: 54.0, 111.4, 122.9, 124.5, 127.3, 128.1, 128.3, 128.5, 129.0, 130.3, 136.4,
137.6, 138.3, 189.3. HRMS calcd for C18H15ClNO: 296.0837 [M+H]+, found: 296.0852.
4-((3-Benzoyl-1H-pyrrol-1-yl)methyl)benzonitrile (8d)
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Yellow solid (81 mg, 57%), mp 103-104 °C. H NMR (600 MHz, CDCl3) δ: 5.17 (s, 2H), 6.69
(s, 1H), 6.75 (s, 1H), 7.21 (d, J = 8.4 Hz, 2H), 7.27 (s, 1H), 7.45 (t, J = 7.8 Hz, 2H), 7.53 (t, J = 7.2
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Hz, 1H), 7.64 (d, J = 7.8 Hz, 2H), 7.82 (d, J = 7.2 Hz, 2H). C NMR (100 Hz, CDCl3) δ: 53.3,
112.0, 112.2, 118.4, 122.8, 125.3, 127.5, 128.2, 128.3, 128.9, 131.6, 132.8, 139.7, 142.0, 190.6.
HRMS calcd for C19H14N2NaO: 309.0998 [M+Na]+, found: 309.1004.
(1-Methyl-1H-pyrrol-3-yl)(phenyl)methanone (8e)3b
Yellow solid (55 mg, 59%), mp 88-89 °C. 1H NMR (600 MHz, CDCl3) δ: 3.67 (s, 3H), 6.62 (s,
1H), 6.67 (s, 1H), 7.16 (s, 1H), 7.43 (t, J = 7.8 Hz, 2H), 7.50 (t, J = 7.2 Hz, 1H), 7.80 (d, J = 8.4
Hz, 2H). 13C NMR (150 Hz, CDCl3) δ: 36.7, 111.1, 123.4, 124.6, 128.2, 128.8, 129.1, 131.3, 140.1,
190.7. HRMS calcd for C12H11NNaO: 208.0733 [M+Na]+, found: 208.0730.
(4-Bromophenyl)(1-methyl-1H-pyrrol-3-yl)methanone (8f)
1
Syrup (79 mg, 60%). H NMR (600 MHz, CDCl3) δ: 3.70 (s, 3H), 6.64 (s, 2H), 7.16 (s, 1H),
7.58 (d, J = 8.4 Hz, 2H), 7.69 (d, J = 8.4 Hz, 2H). 13C NMR (150 Hz, CDCl3) δ: 36.7, 111.1, 123.5,
124.3, 126.0, 128.9, 130.5, 131.4, 138.8, 189.3. HRMS calcd for C12H10BrNNaO: 285.9838
[M+Na]+, found: 285.9842.
3-(3-Benzoyl-1H-pyrrol-1-yl)propanenitrile (8g)15
Syrup (53 mg, 47%). 1H NMR (400 MHz, CDCl3) δ: 2.71 (t, J = 6.8 Hz, 2H), 4.09 (t, J = 6.4 Hz,
2H), 6.60-6.62 (m, 1H), 6.65-6.66 (m, 1H), 7.18-7.19 (m, 1H), 7.33-7.37 (m, 2H), 7.41-7.45 (m,
1H), 7.70-7.72 (m, 2H). 13C NMR (100 Hz, CDCl3) δ: 20.6, 45.5, 111.9, 117.0, 122.1, 125.3, 127.8,
128.3, 128.9, 131.7, 139.7, 190.6. HRMS calcd for C14H12N2NaO: 247.0842 [M+Na]+, found:
247.0849.
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Phenyl(1-phenyl-4,5,6,7-tetrahydro-1H-azepin-3-yl)methanone (10a)
Syrup (91 mg, 66%). 1H NMR (400 MHz, CDCl3) δ: 1.93-2.00 (m, 4H), 2.84 (t, J = 6.4 Hz, 2H),
4.03 (t, J = 6.0 Hz, 2H), 6.96 (d, J = 8.0 Hz, 2H), 7.04 (t, J = 7.2 Hz, 1H), 7.25-7.29 (m, 3H), 7.33-
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7.39 (m, 3H), 7.52 (dd, J1 = 7.6 Hz, J2 = 1.6 Hz, 2H). C NMR (100 Hz, CDCl3) δ: 23.5, 25.3,
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27.5, 50.6, 119.1, 119.4, 123.7, 128.0, 128.5, 129.5, 129.8, 141.2, 146.5, 152.9, 197.1. HRMS
calcd for C19H20NO: 278.1539 [M+H]+, found: 278.1539.
(1-(4-Methoxyphenyl)-4,5,6,7-tetrahydro-1H-azepin-3-yl)(phenyl)methanone (10b)
1
Syrup (109 mg, 71%). H NMR (400 MHz, CDCl3) δ: 1.93-1.97 (m, 4H), 2.84 (t, J = 6.0 Hz,
2H), 3.75 (s, 3H), 3.96 (t, J = 5.6 Hz, 2H), 6.78-6.82 (m, 2H), 6.90-6.94 (m, 2H), 7.19 (s, 1H),
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7.33-7.36 (m, 3H), 7.48-7.50 (m, 2H). C NMR (100 Hz, CDCl3) δ: 23.4, 25.6, 27.7, 51.7, 55.6,
114.6, 117.4, 121.9, 127.9, 128.5, 129.6, 140.6, 141.5, 154.1, 156.6, 196.8. HRMS calcd for
C20H22NO2: 308.1645 [M+H]+, found: 308.1647.
(1-(4-Bromophenyl)-4,5,6,7-tetrahydro-1H-azepin-3-yl)(phenyl)methanone (10c)
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Syrup (115 mg, 65%). H NMR (600 MHz, CDCl3) δ: 1.95-1.96 (m, 4H), 2.82-2.83 (m, 2H),
3.97 (br s, 2H), 6.81 (d, J = 7.8 Hz, 2H), 7.21 (s, 1H), 7.35-7.40 (m, 5H), 7.51 (d, J = 6.6 Hz, 2H).
13C NMR (150 Hz, CDCl3) δ: 23.8, 25.1, 27.4, 50.6, 116.2, 120.2, 120.6, 128.0, 128.5, 130.1,
132.4, 140.9, 145.5, 151.8, 197.2. HRMS calcd for C19H19BrNO: 356.0645 [M+H]+, found:
356.0646.
(1-Phenyl-4,5,6,7-tetrahydro-1H-azepin-3-yl)(p-tolyl)methanone (10d)
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Yellow solid (92 mg, 63%), mp 80-81 °C. H NMR (400 MHz, CDCl3) δ: 1.96-1.98 (m, 4H),
2.35 (s, 3H), 2.83-2.84 (m, 2H), 4.00-4.02 (m, 2H), 6.97 (d, J = 8.8 Hz, 2H), 7.03 (t, J = 7.6 Hz,
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1H), 7.16 (d, J = 7.6 Hz, 2H), 7.26-7.30 (m, 3H), 7.44 (d, J = 8.0 Hz, 2H). C NMR (150 Hz,
CDCl3) δ: 21.4, 23.7, 25.3, 27.5, 50.5, 119.28, 119.33, 123.5, 128.7, 128.8, 129.5, 138.3, 140.2,
146.5, 152.3, 197.0. HRMS calcd for C20H22NO: 292.1696 [M+H]+, found: 292.1678.
(3-Bromophenyl)(1-phenyl-4,5,6,7-tetrahydro-1H-azepin-3-yl)methanone (10e)
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Syrup (105 mg, 59%). H NMR (400 MHz, CDCl3) δ: 1.94-2.01 (m, 4H), 2.82-2.83 (m, 2H),
4.01-4.04 (m, 2H), 6.98 (d, J = 8.8 Hz, 2H), 7.08 (t, J = 7.2 Hz, 1H), 7.20-7.26 (m, 2H), 7.30 (t, J
= 7.6 Hz, 2H), 7.42 (d, J = 7.6 Hz, 1H), 7.51 (dd, J1 = 7.6 Hz, J2 = 0.8 Hz, 1H), 7.66 (d, J = 1.2 Hz,
1H). 13C NMR (150 Hz, CDCl3) δ: 23.5, 25.3, 27.5, 50.9, 118.5, 119.8, 122.2, 124.2, 127.0, 129.57,
129.59, 131.4, 132.7, 143.3, 146.6, 153.4, 195.1. HRMS calcd for C19H19BrNO: 356.0645 [M+H]+,
found: 356.0649.
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(4-Chlorophenyl)(1-phenyl-4,5,6,7-tetrahydro-1H-azepin-3-yl)methanone (10f)
Yellow solid (95 mg, 61%), mp 121-122 °C. 1H NMR (600 MHz, CDCl3) δ: 1.97-1.98 (m, 4H),
2.82-2.83 (m, 2H), 4.02 (br s, 2H), 6.96 (d, J = 7.2 Hz, 2H), 7.07 (t, J = 6.6 Hz, 1H), 7.24 (s, 1H),
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7.28 (t, J = 6.6 Hz, 2H), 7.32 (d, J = 7.8 Hz, 2H), 7.46 (d, J = 7.8 Hz, 2H). C NMR (150 Hz,
CDCl3) δ: 23.6, 25.3, 27.5, 50.9, 118.7, 119.6, 124.1, 128.2, 129.6, 130.0, 135.9, 139.6, 146.6,
152.9, 195.5. HRMS calcd for C19H19ClNO: 312.1150 [M+H]+, found: 312.1149.
2. Scale-up Synthesis of 3a.
To a reaction tube equipped with a stir bar were added 1-phenylpiperidine (1a, 5 mmol),
CH3CN (20 mL), 2-oxo-2-phenylacetic acid (2a, 6 mmol), CuBr2 (0.5 mmol) and TBP (10 mmol)
with stirring. The mixture was stirred under air at 60 °C for 24 h. Then, it was quenched with
water (20 mL), and extracted with ethyl acetate (60 mL  3). The combined organic layers were
washed with brine, dried over anhydrous Na2SO4, and evaporated under reduced pressure. The
residue was purified by column chromatography on silica gel with petroleum ether/ethyl acetate
(5:1) as the eluent to give 3a (0.71 g, 54%).
Supporting Information. Copies of 1H and 13C NMR spectra of all products and the X-ray crystal
structure and data of 3a. This material is available free of charge via the Internet at
http://pubs.acs.org.
Acknowledgments. We are grateful to the National Natural Science Foundation of China (NSFC)
(Grant Nos. 21272058 and 21572047), Program for Innovative Research Team in Science and
Technology in Universities of Henan Province (15IRTSTHN003), Program for Science and
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Technology Innovation Talents in Universities of Henan Province (15HASTIT005), and Plan for
Scientific Innovation Talents of Henan Province (184200510012) for financial support.
References
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