Bioorganic and Medicinal Chemistry Letters p. 2739 - 2744 (2008)
Update date:2022-07-30
Topics:
Wrobleski, Stephen T.
Lin, Shuqun
Hynes Jr., John
Wu, Hong
Pitt, Sidney
Shen, Ding Ren
Zhang, Rosemary
Gillooly, Kathleen M.
Shuster, David J.
McIntyre, Kim W.
Doweyko, Arthur M.
Kish, Kevin F.
Tredup, Jeffrey A.
Duke, Gerald J.
Sack, John S.
McKinnon, Murray
Dodd, John
Barrish, Joel C.
Schieven, Gary L.
Leftheris, Katerina
A novel series of compounds based on the pyrrolo[2,1-f][1,2,4]triazine ring system have been identified as potent p38α MAP kinase inhibitors. The synthesis, structure-activity relationships (SAR), and in vivo activity of selected analogs from this class o
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