
Journal of the Chemical Society. Perkin transactions I p. 471 - 479 (1981)
Update date:2022-07-30
Topics:
Carter, Rachel H.
Garson, Mary J.
Hill, Robert A.
Staunton, James
Sunter, David C.
A flexible synthetic route leading via indan-1-ones to variously methylated and oxygenated isocoumarins is described.The indanones are prepared by alternative routes involving intramolecular Friedel-Crafts cyclisation of arylpropionic acids or pericyclic ring closure of acrylophenones.The influence of substitution on the rate of the pericyclic reaction is assessed.
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