Synthesis of Second-Generation Transition State Analogues of Human Purine Nucleoside Phosphorylase

DOI: 10.1021/jm030305z

Source and publish data:

Journal of Medicinal Chemistry p. 5271 - 5276 (2003)

Update date:2022-08-03

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Authors:

Evans, Gary B.

Furneaux, Richard H.

Lewandowicz, Andrzej

Schramm, Vern L.

Tyler, Peter C.

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Article abstract of DOI:10.1021/jm030305z

Purine nucleoside phosphorylases (PNPs) catalyze nucleophilic displacement reactions by migration of the cationic ribooxacarbenium carbon between the fixed purine and phosphate nucleophiles. As the phosphorolysis reaction progresses along the reaction coo

Full text of DOI:10.1021/jm030305z

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