Tetrahedron p. 3628 - 3635 (2019)
Update date:2022-08-04
Topics:
Zhang, Zhiguo
Li, Xiang
Li, Yinghua
Guo, Yan
Zhao, Xunan
Yan, Yan
Sun, Kai
Zhang, Guisheng
An iodine-promoted, metal-, base-, and solvent-free cross-coupling reaction was developed for the synthesis of various useful secondary amides via an aryl N-addition reaction of aryl groups to cyano groups. This aryl transfer reaction proceeds with arylhydrazine hydrochlorides serving as the aryl donors. A labelling experiment shows that the N atom in the product comes from the cyano group of the nitriles, which are low in cost. A plausible radical-driven mechanism is also proposed.
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