Tetrahedron p. 9909 - 9918 (1994)
Update date:2022-09-26
Topics:
Prokai-Tatrai, Katalin
Zoltewicz, John A.
Kem, William R.
The synthesis and conformational analysis of a "bridged" anabasine, 5,8,9,10,11,11a-hexahydro-6H-pyrido<2,1-f><1,6>naphthyridine (5), and related compounds are reported.Conformational assignments were made using NMR data (including coupling constants, homonuclear Overhauser effects, and 2D correlations) and the results of molecular mechanics (MM2) calculations.The tricyclic compounds have trans-quinolizidine ring fusion with a chair-shaped piperidine ring.The center ring shows a half-chair conformation for the title compound, and a half-boat shape for its 6-oxo derivative.Calculated vicinal coupling constants are in good agreement with those obtained experimentally. Key Words: Bridged anabasine; Conformational analysis; Nuclear Overhauser enhancement; Molecular mechanics.
View MoreHubei Lingsheng Pharmaceuticals Co., Ltd.
Contact:+86-0710-3538058
Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
Contact:86-551-63540590
Address:No 1388 Furong Rd., Hefei, Anhui, China
Shanghai Kangxin Chemical Co., Ltd
Contact:+86 21 60717227
Address:118,Ganbai Village,Waigang Town,Jiading District,Shanghai
TIANJIN ZHONGXIN CHEMTECH CO.,LTD.
Contact:86-022-66880623
Address:FINANCIAL STREET WEST BLK 7, #308, NO.52 XINCHENG WEST ROAD, TEDA, TIANJIN, P.R.CHINA
website:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Doi:10.1021/ja01162a104
(1950)Doi:10.1055/s-1984-30932
(1984)Doi:10.1016/S0040-4039(01)93105-3
(1977)Doi:10.1016/S0020-1693(00)83363-0
(1988)Doi:10.1007/BF00488922
()Doi:10.1002/ejic.201201080
(2013)
