Ferrocenyl polyamines as agents for the chemoimmunotherapy of cancer

Article abstract of DOI:10.1021/jm00202a016

A series of ferrocenyl polyamines, compounds intended to bind to the tumor cell surface nucleic acid and elicit an immune response, was synthesized and screened for antitumor activity. Target ferrocenyl polyamines, bearing 2-, 3-, and 4-amino groups, respectively, were readily obtained in yields of 31-58% from their corresponding ferrocenyl polyamides by reduction with diborane in THF; lithium aluminum hydride was not an effective reducing agent in this case. Although the target compounds failed to prolong the life of mice with P-388 lymphocytic leukemia, three of the intermediate amides did exhibit low but significant activity (T/C=123, 132, and 120%, respectively).