Tetrahedron Letters p. 321 - 324 (2004)
Update date:2022-08-02
Topics:
Leuck, Michael
Vagle, Kurt E.
Roach, J. Shawn
Wolter, Andreas
A novel phosphoramidite reagent was developed to convert terminal hydroxyl groups of oligonucleotides into phosphate monoesters. The reagent's appearance as a solid foam is advantageous for its manipulation and handling in solid phase synthesis and improves its thermal stability.
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