Design, synthesis and biological evaluation of sulfenimine cephalosporin sulfoxides as β-lactamase inhibitors

Article abstract of DOI:10.1016/j.cclet.2015.04.025

Abstract A series of sulfenimine cephalosporin sulfoxide derivatives (7a-v) were designed, synthesized and evaluated for their inhibitory activity against TEM-1 and cephalosporinase in cell-free systems. Some of the tested compounds showed enhanced inhibi

Full text of DOI:10.1016/j.cclet.2015.04.025

WCPT Congress 2015 / Physiotherapy 2015; Volume 101, Supplement 1 eS633–eS832
eS789
the experienced raters was found to be 0.48 with a novice
rater ICC of 0.48 as well. The ICC between all the raters was
0.33.
Conclusion(s): This constitutes poor reliability. The poor
reliability of the technique testing the length of LD was iden-
tified and addressed in order for adequate usage thereof, in
research and in practice. Recommendations of a new tech-
nique to test the length of LD were provided by the researcher.
A suggestion was made regarding a manner of testing its
reliability.
Implications: A reliable technique for assessing the
length of the Latissimus Dorsi muscle will add to objectivity
and consistency in the assessment as well as the management
of human movement related musculo-skelatal conditions.
Keywords: M Latissimus Dorsi; Muscle length test; Dys-
function; Reliability; Reproducibility; Glenoh
Funding acknowledgements: The University of Pretoria.
Ethics approval: The ethics referral number for the pro-
tocol of this study is 464/2013. The Research Ethics Office:
012 354 1677 manda@med.up.ac.za.
atypical depression based on differential in the biological cor-
relates and symptoms presentation of these subtypes, which
may also affect the experience of pain to some extent.
Purpose: The aim of this study was to evaluate the possi-
ble differences in the prevalence of pain between participants
in melancholic and atypical depression subgroups.
Methods: The data of this study was enrolled between
2008 and 2011 in the area of hospital district of Cen-
tral Finland. Participants were 35-75 years old. Depressive
symptoms were determined with Beck Depression Inven-
tory (BDI-21) and depression diagnosis was confirmed with
Mini-International Neuropsychiatric Interview (M.I.N.I.).
Participants were dichotomized into subgroups with melan-
cholic depression (n = 269), atypical depression (n = 144) and
controls(n = 401). Musculoskeletalpainwasidentifiedifpain
occurred frequently or continuously in the joints, back, neck
or was multisite. Also fasting blood samples and oral glucose
tolerance test were drawn.
Results: The prevalence of participants with muscu-
loskeletal pain was 37% in controls, 57% in atypical
depression, and 71% in melancholic depression (p < 0.001,
after adjusting for sex and age). A logistic regression model
showed that the odds ratio of pain after adjusting with
demographic, lifestyle, and biological factors was 2.35 (1.56
to 3.56) with atypical depression compared with controls
(p < 0.001) and 4.38 (3.03 to 6.33) with melancholic depres-
sion compared with atypical depression (p = 0.006). BDI
scores were higher for those with melancholic depression
than for those with atypical depression (p < 0.001), and the
fasting glucose and glucose tolerance were higher for those
with atypical depression compared with controls (p = 0.029
and p = 0.028, respectively).
Conclusion(s): This article shows that melancholic
depression is associated with a higher prevalence of muscu-
loskeletal pain in comparison with atypical depression. This
study highlights the need for further studies about the mech-
anisms behind the association between pain and depression,
and particularly the association with melancholic depression,
and biological differences between melancholic and atypical
depression found in this study as well.
Implications: The presence of pain may negatively affect
recognition and treatment of depression, as most often phys-
ical causes of pain are assessed instead of examining the
broader biopsychosocial context. Primary care providers
should recognize that depression and musculoskeletal pain
often coexists and further, should be aware of the depression
subtype as they may respond a distinct treatment and reha-
bilitation. Patients with melancholic depression may require
more detailed and effective treatment of depression, and those
with atypical depression may also benefit from lifestyle coun-
seling.
http://dx.doi.org/10.1016/j.physio.2015.03.3667
Research Report Platform Presentation
Number: RR-PL-3732
Monday 4 May 2015 15:02
Room 334–335
MUSCULOSKELETAL PAIN IN
MELANCHOLIC AND ATYPICAL
DEPRESSION
K. Korniloff1, S. Kotiaho2, M. Vanhala3,4
H. Kautiainen5, H. Koponen6,
P. Mäntyselkä4
,
1 University of Jyväskylä, Department of Health Sciences,
Jyväskylä, Finland; 2 Saarikka Primary Care Public Utility,
Saarijärvi, Finland; 3 Primary Health Care Unit, Central
Finland Central Hospital, Jyväskylä, Finland; 4 Unit of
Primary Health Care, University of Eastern Finland and
Kuopio University Hospital, Kuopio, Finland; 5 Unit of
Primary Health Care, Kuopio University Hospital, Kuopio,
Unit of Primary Health Care, Helsinki University Central
Hospital and Department of General Practice, University of
Helsinki, Helsinki, Finland; 6 University of Helsinki and
Helsinki University Hospital, Psychiatry, Helsinki, Finland
Background: Pain and depressive disorders often present
together. On average, 65% of patients with depression are
identified as simultaneously having pain, and the preva-
lence of pain symptoms is as high as 69% in primary care
patients with depression. Comorbidity of chronic pain and
depression has been consistently associated with a poorer
prognosis and greater disability in patients when compared
with those suffering from each illness alone. Depression can
be dichotomized into subgroups with mainly melancholic and
Keywords: Musculoskeletal pain; Depressive disorder;
Melancholia
Funding acknowledgements: Study was supported by
financing from the Hospital District of Central Finland and
Yrjö Jahnsson Foundation.

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WCPT Congress 2015 / Physiotherapy 2015; Volume 101, Supplement 1 eS633–eS832
Ethics approval: Ethical permission for the study was
granted by the Hospital District of Central Finland Ethics
Committee.
addition to tutorials students see multiple teaching methods
as important. Professional identity starts developing when
students face a real patient in instructed practical training.
The main episodes of professional development are:
earlier studies, new way of learning, understanding the phys-
iotherapy and turning to be professional in physiotherapy.
Three story models based on the students’ stories were
formed: the story of the development of an autonomous
learner, the story of becoming a physiotherapy community
member and the story of the development of critical devel-
oper.
http://dx.doi.org/10.1016/j.physio.2015.03.3668
Special Interest Report Poster Presentation
Number: SI-PO-08-21-Mon
Monday 4 May 2015 12:15
Exhibit halls 401–403
Conclusion(s): The results of the study help to understand
the entirety of professional development and professional
development when using PBL method in learning. The criti-
cal stages of learning become clear in the four-level transition
-steps of the physiotherapy students’ professional develop-
ment. Especially seeing the turning points of the story models
help to recognize when the different kinds of learners need
guidance the most.
PROBLEM-BASED LEARNING IN
PHYSIOTHERAPY STUDENTS’
DEVELOPMENT FOR EXPERTS
H. Korpi, A. Piirainen, L. Peltokallio
University of Jyväskylä, Faculty of Sport and Health
Sciences, Department of Health Sciences, Jyväskylä,
Finland
Implications: The knowledge is useful to create new
curricula for physiotherapy students’ programmes. It is
important to take into account the stories of how to become
a physiotherapist and the critical turning points in students’
learning process.
Keywords: Problem-based learning; Physiotherapy stu-
dent; Narrative research
Funding acknowledgements: The work was unfunded.
Ethics approval: The University of Jyväskylä Ethical
Committee 2012.
Background: Problem-based learning (PBL) has become
a significant approach in vocational education since 1980’s.
Nowadays PBL is used in 5 out of 15 physiotherapy education
units in Finland. The study brings new information about
continuous learning for developing physiotherapy education
and its curricula. European Qualification Framework (EQF)
defines the key competences of the education, but it does not
define those individual study paths, which help the students
to reach their goals.
Purpose: The aim of the study is to investigate physiother-
apy students’ development for experts in Finnish university
of applied sciences, which uses problem-based learning as
their approach.
Methods: The study had a qualitative, narrative approach
to describe and understand the physiotherapy students’
stories as narratives. Longitudinal data written by eleven vol-
untary students (mean age 24.5 years) was collected during
3.5 years from a university of applied sciences in Finland. The
data consists of 802 typewritten A4 pages of learning expe-
riences of the students. This data tells about them as learners
and their development process. Students wrote their portfo-
lios every 6 months, in which they described their learning
experiences and feelings. Students were given guidance in
making a portfolio. The lengths of the stories varied from 25
to 286 pages; on average they wrote 73 pages. The writing
was free narration from the students. Finally, the portfolio
consisted of a single report of their study time.
Results: The use of PBL method in teaching “stops” all
students at the beginning of their studies. The new way of
learning creates enthusiasm in a part of the students, but at
the same time it brings fear about not learning everything
essential. Information seeking skills and ability to work in a
groupareexperiencedasneededwhenusingthePBLmethod.
Critical and analytical relation to learning is seen in the stu-
dents’storiesalreadyinthebeginningofstudies. Thestudents
also think about problems they face in real working life. In
http://dx.doi.org/10.1016/j.physio.2015.03.3669
Research Report Poster Presentation
Number: RR-PO-15-18-Mon
Monday 4 May 2015 13:00
Exhibit halls 401–403
DEVELOPMENT OF THE TOILET
ASSISTANCE CHART AND EXAMINATION
OF ITS VALIDITY IN A CONVALESCENT
REHABILITATION WARD
M. Kota1, J. Ushirogochi1, K. Kobayashi1,
H. Sunahori1, H. Hirayama1, H. Kudo1,
A. Shirai2
1 Hiroshima City Rehabilitation Hospital, Department of
Rehabilitation, Hiroshima City, Japan; 2 Hiroshima City
Rehabilitation Hospital, Department of Nurse, Hiroshima
City, Japan
Background: Convalescent rehabilitation wards in Japan
house many patients who need assistance with toilet-related
activities. Theindependenceleveloftoilet-relatedactivitiesis
usually assessed using the Functional Independence Measure
(FIM). The FIM includes some toilet-related items such as
dressing the lower body, toileting, transfers, and locomotion.