Chemistry of Natural Compounds p. 703 - 708 (1982)
Update date:2022-08-03
Topics: Oligonucleotides Nucleotidopeptides XLII Efficacy of the intramolecular influence of the carboxy groups of amino acids As a function of their positions
Yuodka, B. A.
Lioranchaite, L. E.
Baltenas, V. R.
It has been established that remote carboxy groups in nucleotidyl-(5'-->N)-β-alanine and -alanylalanine do not affect the mechanism of the cleavage of the phosphoramide center.The situation is different in the case of nucleotidyl-(5'-->Nε)-lysine.It has been shown that in the 3'-phenylalanine derivative of dTMP, the influence of the α-carboxy group of the amino acid is only half as great as in the 5'-analog.The α-carboxy groups of the amino acids in oligonucleotidyl-(Pin-->N)-amino acids also weaken the mechanism of the cleavage of the phosphoramide centers.
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