Bioorganic and Medicinal Chemistry Letters p. 4143 - 4150 (2005)
Update date:2022-08-04
Topics:
Lee, Jeewoo
Jin, Mi-Kyoung
Kang, Sang-Uk
Su, Yeon Kim
Lee, Jiyoun
Shin, Myoungyoup
Hwang, Jaemin
Cho, Sookhyun
Choi, Yeon-Sil
Choi, Hyun-Kyung
Kim, Sung-Eun
Suh, Young-Ger
Lee, Yong-Sil
Kim, Young-Ho
Ha, Hee-Jin
Toth, Attila
Pearce, Larry V.
Tran, Richard
Szabo, Tamas
Welter, Jacqueline D.
Lundberg, Daniel J.
Wang, Yun
Lazar, Jozsef
Pavlyukovets, Vladimir A.
Morgan, Matthew A.
Blumberg, Peter M.
The structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. A docking model of potent antagonist 2 with the sensor region of TRPV1 is proposed.
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