Characterization of autoxidation products of the antifungal compounds econazole nitrate and miconazole nitrate

DOI: 10.1016/S0040-4020(01)82309-7

Source and publish data:

Tetrahedron p. 6549 - 6560 (1991)

Update date:2022-08-02

Topics:

Authors:

Oyler Oyler

Naldi Naldi

Facchine

Burinsky

Cozine Cozine

Dunphy Dunphy

Alves-Santana

Cotter Cotter

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Article abstract of DOI:10.1016/S0040-4020(01)82309-7

Econazole nitrate 1 and miconazole nitrate 2 underwent autoxidation in 90% ethanol at 77°C in the presence of AIBN and oxygen. The benzylic methylene carbons of 1 and 2, the benzylic methine carbon of 2, and the imidazole ring of 2 were sites of oxidation.

Full text of DOI:10.1016/S0040-4020(01)82309-7

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