Simple entry into isonucleosides: Synthesis of 6-amino-9-[(3S,4S,5R)-4- hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl]purine

Article abstract of DOI:10.1016/j.tetlet.2004.02.021

A simple and efficient method for the preparation of isonucleoside 7 is described. The preparation of 1,4-anhydroxylitol 4, a key intermediate, is described by intramolecular cyclization of (2S,3R,4R)-3,5-dibenzyloxypentan-1,2, 4-triol 3 using diethyl car