Significant Differences in Biological Parameters between Prodrugs Cleavable by Carboxypeptidase G2 That Generate 3,5-Difluoro-phenol and -aniline Nitrogen Mustards in Gene-Directed Enzyme Prodrug Therapy Systems

DOI: 10.1021/jm030966w

Source and publish data:

Journal of Medicinal Chemistry p. 2651 - 2658 (2004)

Update date:2022-08-03

Topics:

Authors:

Niculescu-Duvaz

Scanlon Scanlon

Niculescu-Duvaz

Friedlos

Martin Martin

Marais Marais

Springer

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Article abstract of DOI:10.1021/jm030966w

Nine new nitrogen mustard compounds derived from 2,6-difluoro-4-hydroxy- (3a-e) and 2,6-difluoro-4-amino- (4a-d) aniline were synthesized as potential prodrugs. They were designed to be activated to their corresponding 3,5-difluorophenol and -aniline (4)-

Full text of DOI:10.1021/jm030966w

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