Significant Differences in Biological Parameters between Prodrugs Cleavable by Carboxypeptidase G2 That Generate 3,5-Difluoro-phenol and -aniline Nitrogen Mustards in Gene-Directed Enzyme Prodrug Therapy Systems

DOI: 10.1021/jm030966w

Source and publish data:

Journal of Medicinal Chemistry p. 2651 - 2658 (2004)

Update date:2022-08-03

Topics:

Authors:

Niculescu-Duvaz

Scanlon Scanlon

Niculescu-Duvaz

Friedlos

Martin Martin

Marais Marais

Springer

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm030966w

Nine new nitrogen mustard compounds derived from 2,6-difluoro-4-hydroxy- (3a-e) and 2,6-difluoro-4-amino- (4a-d) aniline were synthesized as potential prodrugs. They were designed to be activated to their corresponding 3,5-difluorophenol and -aniline (4)-

Full text of DOI:10.1021/jm030966w

Products guided by the article

Product name:2,6-difluoro-[bis(2-hydroxyethyl)]aniline

Cas No:694504-20-6

R&D Labs maybe for 694504-20-6

Jinan Baozhao Pharmaceutical Co., Ltd

Contact:0086-531-86397156 82371858 82371868

Address:Huaneng Road, Jinan, Shandong ,China
Chengdu Pukang Biotechnology Co., Ltd

Contact:+86-28-82550498

Address:No. 558 Rulin Road,Xinjin county,Chengdu city, China
wuxi huabin bio-tech Co.,Ltd(expird)

Contact:86-0510-85133006

Address:hubin road NO157
Jiangxi Dongbang Pharmaceutical Co., Ltd.

Contact:+86-795-4433603, 4433388

Address:Fengxin Industrial Park, Fengxin County, Jiangxi Province, P.R.C
Jiangxi Huashi Pharmaceutical Co., Ltd

Contact:+86-795-4509628

Address:Ningbo Ave., Fengtian Industrial Park, Fengxin Country, Jiangxi, China.

Relevant to this article

STRUCTURE OF A NEW CHALCONE AMMOTHAMNIDIN FROM Ammothamnus lehmanni

Doi:10.1007/BF00575695
(1983)
LONG-ACTING CONTRACEPTIVE AGENTS: ESTERS OF NORETHISTERONE WITH ALKOXY- AND HALOGENO-SUBSTITUTED CARBOXYLIC ACIDS

Doi:10.1016/0039-128X(83)90099-5
(1983)
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)

Doi:10.1016/j.bmc.2014.09.012
(2014)
A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H₃ receptor: Effect of various substitutions at the primary amino function

Doi:10.1021/jm0504353
(2006)
Deprotonation mechanism and log P values of new antihypertensive thiomorpholinylmethylphenols: A combined experimental and theoretical study

Doi:10.1021/je100470g
(2010)
Cu(OTf)₂-catalyzed synthesis of imidazo[1,2-a]pyridines from α-diazoketones and 2-aminopyridines

Doi:10.1016/j.tetlet.2007.08.090
(2007)

Article Doi