First functionalization by metallation of the pyridine moiety of pyridopyrimidin-4(3H)-ones. Diazines. Part 36

Article abstract of DOI:10.1016/j.tet.2004.02.040

Starting from o-aminopyridine carboxylic acids, a general synthetic route leading to various pyridopyrimidin-4(3H)-ones is described. The first metallation and functionalization of the pyridine moiety has been studied and a regioselective metallation at the peri-position C₅ of the pyridine ring has been highlighted.