SYNTHESE DE PHOSPHONATES β-CARBONYLES I. PAR VOIE CARBANIONIQUE

Article abstract of DOI:10.1016/0022-328X(84)85128-1

Condensation of a lithiated phosphonate carbanion not bearing a stabilizing group with a carbonyl precursor (amide or ester) gives an intermediate oxyanion which decomposes on hydrolysis to yield a β-carbonyl phosphonate.This type of reaction gives access to a large group of phosphonates: β-ketophosphonates, phosphonic aldehydes, phosphonopyruvates etc.The reaction conditions are discussed.