Journal of labelled compounds and radiopharmaceuticals p. 501 - 506 (1979)
Update date:2022-07-30
Topics:
Johnson Jr.
Cernosek Jr.
Gutierrez-Cernosek
The mixed anhydride synthesis provides a route to an iodinated form of the synthetic estrogen diethylstilbestrol (DES). Labelling of histamine by the oxidative Chloramine-T method prior to coupling to 4-O-(carboxypropyl)-diethylstilbestrol minimizes radiation damage to the sensitive DES derivative. The radioiodinated derivative has demonstrated binding to an anti-DES serum, thus making possible a potentially useful iodine-based radioimmunoassay for DES.
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(1963)
