Tetrahedron Letters p. 5306 - 5310 (2014)
Update date:2022-08-02
Topics:
Ghezal, Salma
Thomasson, Maggie S.
Lefebvre-Tournier, Isabelle
Périgaud, Christian
Macnaughtan, Megan A.
Roy, Béatrice
Herein we report a one-pot multi-step synthesis of the cofactors CDP-Ethanolamine and CDP-Choline starting from cytidine 5′-monophosphate and using commercially available and/or easily prepared reagents. While studying the 31P NMR spectrum of CDP-Ethanolamine, an unexpected characteristic for a pyrophosphate diester was observed as it showed a singlet or two doublets depending upon the pH. Therefore, further NMR studies were undertaken to investigate the pH dependence of the peak splitting pattern and measure the acid dissociation constants of the compounds.
View MoreShanghai SMEC Trading Co., Ltd.
website:http://www.shanghaismec.com
Contact:+86-21-68811293
Address:ROOM 1101,NO.800 SHANGCHENG RD,SHANGHAI,CHINA
Changzhou Jiana Chemical Co.,Ltd
website:http://www.jianachem.com
Contact:86-0519-88731808
Address:Zhenglu Town Wujin City, Jiangsu Province
website:http://www.amadischem.com
Contact:86-571-89925085
Address:Watts Cosine.No.166.Xiangmao Road.
Contact:0572-2722882
Address:1201,F3,xinghuibandao,
suzhou BetterBioChem Co., Ltd.
website:http://www.betterbiochem.com
Contact:+86-18013506594
Address:No. 8 Building, 18 nong, Xi Yingnan Road, Pudong, Shanghai,China
Doi:10.1021/jm00363a020
(1983)Doi:10.1016/S0040-4020(01)93741-X
(1979)Doi:10.1016/S0040-4039(01)86417-0
(1979)Doi:10.1055/s-2004-822890
(2004)Doi:10.1021/jo01369a018
(1954)Doi:10.1016/j.bmc.2020.115610
(2020)