Journal of Organic Chemistry p. 2297 - 2301 (1980)
Update date:2022-08-03
Topics:
Konopelski, Joseph P.
Djerassi, Carl
Two syntheses of (R)-(+)-2,2-dimethyl-4-tert-butylcyclohexanone (1) are presented.Related 4-alkylcyclohexanones (intermediates in the syntheses) bear other (potential) conformational anchoring groups.The key steps in the syntheses are the opening of the cyclobutane ring of (+)-3,3-dimethylnopinone (10) by either pyrolysis or reaction with BBr3.The high optical purity of the final compound was determined by analysis of the 19F NMR spectrum of the diastereomeric ester mixture obtained from the reaction of alcohol (+)-14b with (S)-(+)-MTPA chloride
View MoreJiangsu Taihu New Materials Holding Co., Ltd
Contact:+86-519-86160108
Address:Xueyan Town, Changzhou City, Jiangsu Province, 213169, China
Contact:+65 9658 0999
Address:26 Sin Ming Lane, Midview City, #05-118, Singapore 573971
Tianjin Ingenochem Technology Co.,Ltd
Contact:+86-22-23677060
Address:Hitech Green Industry Park K2-9-602, Nankai district
Shanghai Egoal Chemical Co.,Ltd
Contact:+86-21-50333091
Address:Yangming Garden Square 3,YangGao North Road 1188, Pudong New District, Shanghai
Jiaxing Trustworthy Import And Export Co.,Ltd
Contact:+86-573-82030555
Address:Room 1202, Unit B, Charming plaza,No.1558 East Zhongshan Road , Jiaxing City, Zhejiang Province, China.
Doi:10.1007/s10593-013-1381-3
(2013)Doi:10.1021/ic302759k
(2013)Doi:10.1248/cpb.c13-00356
(2013)Doi:10.1016/j.ejmech.2013.08.041
(2013)Doi:10.1021/ja409006y
(2013)Doi:10.1016/j.tet.2019.01.013
(2019)
