Inhibitors of sterol synthesis. Synthesis and spectral properties of 3β-hydroxy-5α-cholestan-15-one and its 14β-epimer and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity

Article abstract of DOI:10.1016/0009-3084(94)90106-6

3β-Hydroxy-5α-cholestan-15-one (2a) and its 14β-epimer 2b were prepared from 3β-acetoxy-5α-cholest-8(14)-ene (3). Hydroboration of 3 at 45-50°C gave a mixture of 5α,14α-cholestane-3β,15α-diol and 5α,14β-cholestane-3β,15β-diol, which were separated on sili