Journal of Organic Chemistry p. 2739 - 2740 (1980)
Update date:2022-08-03
Topics:
Yamamoto, Hisashi
Maruoka, Keiji
A mild and efficient method for the N-alkylation of amines is described, based on the oxidative coupling of lithium alkylcopper amide, which is derived from lithium dialkylcuprates and primary or secondary amines.The high chemospecificity of the method was demonstrated.
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