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tion of the quaternary carbon center in spirocyclic ox-
indole-lactones is under way in our laboratory.
Experimental Section
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Typical Procedure
To a solution of 3-indolepropionic acids 1 (0.10 mmol) in
CH3CN(1.0 mL) was added NaI (10 mol%) followed by
30% H2O2 (6 equiv.). The reaction mixture was stirred at
room temperature until completion of the reaction. After
this time, the solvent was removed under vacuum and the
residue was purified by flash column chromatography (pe-
troleum ether/AcOEt) to give the pure desired product 2.
Acknowledgements
We gratefully acknowledge financial support from the NSFC
(21432003, 21572278 and 21502079) and the Program for
Chang-Jiang Scholars and Innovative Research Team in Uni-
versity (IRT 15R27).
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